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Anxiolytic-like effect of a novel peptide isolated from the venom of the social wasp Synoeca surinama.
Gomes, Flávia M M; Paniago, Cássia K; Freire, Daniel O; Souza, Adolfo C B; Lima, Marcos R; Oliveira-Júnior, Nelson G; Franco, Octavio L; Mortari, Márcia R.
Afiliação
  • Gomes FM; Neuropharmacology Laboratory, Department of Physiological Sciences, Institute of Biological Sciences, University of Brasília, Brasília, Brazil. Electronic address: flaviia.medeiros@hotmail.com.
  • Paniago CK; Neuropharmacology Laboratory, Department of Physiological Sciences, Institute of Biological Sciences, University of Brasília, Brasília, Brazil. Electronic address: paniago.bio@gmail.com.
  • Freire DO; Neuropharmacology Laboratory, Department of Physiological Sciences, Institute of Biological Sciences, University of Brasília, Brasília, Brazil. Electronic address: daniel.microbiologia@gmail.com.
  • Souza AC; Neuropharmacology Laboratory, Department of Physiological Sciences, Institute of Biological Sciences, University of Brasília, Brasília, Brazil. Electronic address: adolfo_quimica@hotmail.com.
  • Lima MR; Neuropharmacology Laboratory, Department of Physiological Sciences, Institute of Biological Sciences, University of Brasília, Brasília, Brazil; Evolutionary Ecology Laboratory, Department of Animal and Plant Biology, Biological Sciences Center, State University of Londrina, Londrina, Brazil. Electro
  • Oliveira-Júnior NG; S-Inova Biotech, Post-Graduation on Biotechnology, Dom Bosco Catholic University, Campo Grande, Brazil; Center for Biochemical and Proteomics Analyses, Catholic University of Brasília, Brasília, Brazil. Electronic address: juroyal@gmail.com.
  • Franco OL; S-Inova Biotech, Post-Graduation on Biotechnology, Dom Bosco Catholic University, Campo Grande, Brazil; Center for Biochemical and Proteomics Analyses, Catholic University of Brasília, Brasília, Brazil. Electronic address: ocfranco@gmail.com.
  • Mortari MR; Neuropharmacology Laboratory, Department of Physiological Sciences, Institute of Biological Sciences, University of Brasília, Brasília, Brazil. Electronic address: mmortari@unb.br.
Toxicon ; 122: 39-42, 2016 Nov.
Article em En | MEDLINE | ID: mdl-27664832
Pathological anxiety is among the most common psychiatric illnesses, but current treatment is highly limited. In this study, we investigated the potential anxiolytic-like effects of a peptide isolated from Synoeca surinama venom. Rats treated with this peptide spent more time exploring the open arms of elevated plus maze, which indicates an anxiolytic-like profile for this peptide. This study is the first to show the pharmacological use of S. surinama venom in the treatment of anxiety.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeos / Ansiolíticos / Venenos de Vespas Limite: Animals Idioma: En Revista: Toxicon Ano de publicação: 2016 Tipo de documento: Article País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeos / Ansiolíticos / Venenos de Vespas Limite: Animals Idioma: En Revista: Toxicon Ano de publicação: 2016 Tipo de documento: Article País de publicação: Reino Unido