CRP/IL-6/IL-10 Single-Nucleotide Polymorphisms Correlate with the Susceptibility and Severity of Community-Acquired Pneumonia.

ABSTRACT

OBJECTIVE: To explore the associations of single-nucleotide polymorphisms (SNPs) of the C-reactive protein (CRP), interleukin 6 (IL-6) and IL-10 genes with susceptibility and severity of community-acquired pneumonia (CAP). MATERIALS AND METHODS: Two hundred seventy-nine CAP patients were selected for the case group and 156 healthy individuals for the control group. Polymerase chain reaction-restriction fragment length polymorphism was performed for genotyping of CRP +1059G/C (rs1800947) and +1846C/T (rs1205), IL-6 -597G/A (rs1800797) and -572C/G (rs1800796), and IL-10 -592C/A (rs1800872) and -1082G/A (rs1800896). According to CURB-65 score, the patients were assigned into the severe community-acquired pneumonia (SCAP) and non-SCAP groups. RESULTS: The frequencies of the CRP +1846C/T (rs1205) (CT+TT) genotypes and T allele, the IL-6 -597G/A (rs1800797) (AA+AG) genotypes and A allele, and the IL-10 -592C/A (rs1800872) (CA+AA) genotypes and A allele were higher in the case group than the control group. Furthermore, the frequencies of the CRP +1846C/T (rs1205) (CT+TT) genotypes and T allele, the IL-6 -597G/A (rs1800797) A allele, and the IL-10 -592C/A (rs1800872) (CA+AA) genotypes and A allele were higher in the SCAP group than in the non-SCAP group. CONCLUSION: The CRP +1846C/T (rs1205), IL-6 -597G/A (rs1800797), and IL-10 -592C/A (rs1800872) may be associated with the susceptibility and severity of CAP.