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KCNE1 induces fenestration in the Kv7.1/KCNE1 channel complex that allows for highly specific pharmacological targeting.
Wrobel, Eva; Rothenberg, Ina; Krisp, Christoph; Hundt, Franziska; Fraenzel, Benjamin; Eckey, Karina; Linders, Joannes T M; Gallacher, David J; Towart, Rob; Pott, Lutz; Pusch, Michael; Yang, Tao; Roden, Dan M; Kurata, Harley T; Schulze-Bahr, Eric; Strutz-Seebohm, Nathalie; Wolters, Dirk; Seebohm, Guiscard.
Afiliação
  • Wrobel E; Department of Cardiovascular Medicine, Institute for Genetics of Heart Diseases (IfGH), University Hospital Muenster, Muenster D-48149, Germany.
  • Rothenberg I; Department of Cardiovascular Medicine, Institute for Genetics of Heart Diseases (IfGH), University Hospital Muenster, Muenster D-48149, Germany.
  • Krisp C; Department of Analytical Chemistry, Ruhr University of Bochum, Universitaetsstrasse 150, Bochum 44801, Germany.
  • Hundt F; Department of Analytical Chemistry, Ruhr University of Bochum, Universitaetsstrasse 150, Bochum 44801, Germany.
  • Fraenzel B; Department of Analytical Chemistry, Ruhr University of Bochum, Universitaetsstrasse 150, Bochum 44801, Germany.
  • Eckey K; Department of Cardiovascular Medicine, Institute for Genetics of Heart Diseases (IfGH), University Hospital Muenster, Muenster D-48149, Germany.
  • Linders JT; Project Management Office, Janssen Research &Development, a Division of Janssen Pharmaceutica N.V., 2340 Beerse, Belgium.
  • Gallacher DJ; Safety Pharmacology Research, Translational Sciences, Janssen Research &Development, a Division of Janssen Pharmaceutica N.V., 2340 Beerse, Belgium.
  • Towart R; Safety Pharmacology Research, Translational Sciences, Janssen Research &Development, a Division of Janssen Pharmaceutica N.V., 2340 Beerse, Belgium.
  • Pott L; Institute of Physiology, Ruhr University of Bochum, Universitaetsstrasse 150, Bochum 44801, Germany.
  • Pusch M; Istituto di Biofisica CNR, Via De Marini 6, Genova I-16149, Italy.
  • Yang T; Departments of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
  • Roden DM; Departments of Medicine, Pharmacology and Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
  • Kurata HT; Department of Pharmacology, University of Alberta, 9-70 Medical Sciences Building, Edmonton, Alberta, Canada T6G 2R3.
  • Schulze-Bahr E; Department of Cardiovascular Medicine, Institute for Genetics of Heart Diseases (IfGH), University Hospital Muenster, Muenster D-48149, Germany.
  • Strutz-Seebohm N; Department of Cardiovascular Medicine, Institute for Genetics of Heart Diseases (IfGH), University Hospital Muenster, Muenster D-48149, Germany.
  • Wolters D; Department of Analytical Chemistry, Ruhr University of Bochum, Universitaetsstrasse 150, Bochum 44801, Germany.
  • Seebohm G; Department of Cardiovascular Medicine, Institute for Genetics of Heart Diseases (IfGH), University Hospital Muenster, Muenster D-48149, Germany.
Nat Commun ; 7: 12795, 2016 10 12.
Article em En | MEDLINE | ID: mdl-27731317
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Adamantano / Ativação do Canal Iônico / Canais de Potássio de Abertura Dependente da Tensão da Membrana / Bloqueadores dos Canais de Potássio / Canal de Potássio KCNQ1 Limite: Animals / Humans Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Alemanha País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Adamantano / Ativação do Canal Iônico / Canais de Potássio de Abertura Dependente da Tensão da Membrana / Bloqueadores dos Canais de Potássio / Canal de Potássio KCNQ1 Limite: Animals / Humans Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Alemanha País de publicação: Reino Unido