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A CRISPR Dropout Screen Identifies Genetic Vulnerabilities and Therapeutic Targets in Acute Myeloid Leukemia.
Tzelepis, Konstantinos; Koike-Yusa, Hiroko; De Braekeleer, Etienne; Li, Yilong; Metzakopian, Emmanouil; Dovey, Oliver M; Mupo, Annalisa; Grinkevich, Vera; Li, Meng; Mazan, Milena; Gozdecka, Malgorzata; Ohnishi, Shuhei; Cooper, Jonathan; Patel, Miten; McKerrell, Thomas; Chen, Bin; Domingues, Ana Filipa; Gallipoli, Paolo; Teichmann, Sarah; Ponstingl, Hannes; McDermott, Ultan; Saez-Rodriguez, Julio; Huntly, Brian J P; Iorio, Francesco; Pina, Cristina; Vassiliou, George S; Yusa, Kosuke.
Afiliação
  • Tzelepis K; Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.
  • Koike-Yusa H; Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.
  • De Braekeleer E; Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.
  • Li Y; Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.
  • Metzakopian E; Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.
  • Dovey OM; Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.
  • Mupo A; Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.
  • Grinkevich V; Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.
  • Li M; Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.
  • Mazan M; Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.
  • Gozdecka M; Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.
  • Ohnishi S; Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.
  • Cooper J; Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.
  • Patel M; Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.
  • McKerrell T; Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.
  • Chen B; Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.
  • Domingues AF; Department of Haematology, NHS Blood and Transplant, Cambridge Biomedical Campus, University of Cambridge, Cambridge CB2 0PT, UK.
  • Gallipoli P; Department of Haematology, Cambridge University Hospitals NHS Trust, Cambridge CB2 0QQ, UK; Wellcome Trust-MRC Stem Cell Institute, Cambridge Biomedical Campus, University of Cambridge, Cambridge CB2 0XY, UK.
  • Teichmann S; Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.
  • Ponstingl H; Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.
  • McDermott U; Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.
  • Saez-Rodriguez J; European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, Cambridge CB10 1SD, UK; Faculty of Medicine, Joint Research Center for Computational Biomedicine, RWTH Aachen, 52074 Aachen, Germany.
  • Huntly BJP; Department of Haematology, Cambridge University Hospitals NHS Trust, Cambridge CB2 0QQ, UK; Wellcome Trust-MRC Stem Cell Institute, Cambridge Biomedical Campus, University of Cambridge, Cambridge CB2 0XY, UK.
  • Iorio F; European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, Cambridge CB10 1SD, UK.
  • Pina C; Department of Haematology, NHS Blood and Transplant, Cambridge Biomedical Campus, University of Cambridge, Cambridge CB2 0PT, UK. Electronic address: cp533@medschl.cam.ac.uk.
  • Vassiliou GS; Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK; Department of Haematology, Cambridge University Hospitals NHS Trust, Cambridge CB2 0QQ, UK; Wellcome Trust-MRC Stem Cell Institute, Cambridge Biomedical Campus, University of Cambridge, Cambridge CB2 0XY, UK. Electronic address: gsv20
  • Yusa K; Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK. Electronic address: ky1@sanger.ac.uk.
Cell Rep ; 17(4): 1193-1205, 2016 10 18.
Article em En | MEDLINE | ID: mdl-27760321
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Leucemia Mieloide Aguda / Testes Genéticos / Terapia de Alvo Molecular / Repetições Palindrômicas Curtas Agrupadas e Regularmente Espaçadas Tipo de estudo: Prognostic_studies Limite: Adult / Humans Idioma: En Revista: Cell Rep Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Reino Unido País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Leucemia Mieloide Aguda / Testes Genéticos / Terapia de Alvo Molecular / Repetições Palindrômicas Curtas Agrupadas e Regularmente Espaçadas Tipo de estudo: Prognostic_studies Limite: Adult / Humans Idioma: En Revista: Cell Rep Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Reino Unido País de publicação: Estados Unidos