Examining the protective effects of acetyl l-carnitine on cisplatin-induced uterine tube toxicity.
J Obstet Gynaecol
; 36(8): 1086-1092, 2016 Nov.
Article
em En
| MEDLINE
| ID: mdl-27786574
ABSTRACT
The aim of this study was to investigate the effects of cisplatin and the protective role of acetyl l-carnitine against uterine tube toxicity. Twenty-four female Wistar albino rats were divided into four groups control group was injected with saline (control); group 2 was injected with acetyl l-carnitine; group 3 was injected with cisplatin; and group 4 was pre-treated with acetyl l-carnitine before cisplatin intraperitoneal injection. According to our results, a significant weight loss was observed in rats from group 3. The thickness of the wall and epithelium of uterine tube were decreased in group 3 rats. We elaborate the protein expression of caspase in epithelium and stroma by IHC. We found that the expression of caspase and the number of TUNEL-positive cells were increased in group 3 rats compared to the other groups. In our study, we showed the protective role of acetyl l-carnitine against uterine tube toxicity caused by cisplatin.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Acetilcarnitina
/
Complexo Vitamínico B
/
Cisplatino
/
Tubas Uterinas
/
Antineoplásicos
Limite:
Animals
Idioma:
En
Revista:
J Obstet Gynaecol
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Turquia