Searching for anti-glioma activity. Ribonucleoside analogues with modifications in nucleobase and sugar moieties.
Acta Biochim Pol
; 63(4): 765-771, 2016.
Article
em En
| MEDLINE
| ID: mdl-27830840
ABSTRACT
Several ribonucleoside analogues with modifications in the nucleobase and sugar moiety have been screened for anti-glioma activity in the T98G glioma cell line using cervical (HeLa) cell line as reference human malignant cells, and lung fibroblast (MCR-5) cell line as non-cancerous reference cells. Among the investigated compounds, ribonucleosides containing 6-chloropurine (3), 7-guanine (5) and a pyrrolopyrimidine (18) as nucleobases, show promising anti-glioma activity with good selectivity indices, and can be considered as lead structures for further anti-cancer studies.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Adenosina
/
Citidina
/
Guanosina
/
Antineoplásicos
Limite:
Humans
Idioma:
En
Revista:
Acta Biochim Pol
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Polônia