Suppression of cytotoxic T cell induction in vivo by prodigiosin 25-C.
Transplantation
; 47(6): 1013-6, 1989 Jun.
Article
em En
| MEDLINE
| ID: mdl-2786655
Prodigiosin 25-C (PrG25-C) was discovered as an immunosuppressant in the course of our screening for immunomodulating substances. In this system, PrG25-C inhibited T lymphocytes proliferation and was less suppressive against B lymphocytes. PrG25-C was also a powerful inhibitor of cytotoxic T cell induction by mixed lymphocyte reaction and completely suppressed induction of H-2 specific cytotoxic cells at 12.7 nM. PrG25-C also inhibited in vivo induction of H-2 restricted cytotoxic T lymphocytes at a dose of 0.5 mg/kg but had little myelotoxicity because numbers of blood leukocytes and splenocytes of PrG25-C-treated mice were comparable to those of nonsensitized mice. No inhibitory effects of PrG25-C were observed on the production of anti-SRBC antibody. These results indicate that PrG25-C is a T-lymphocyte-specific immunosuppressant.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Prodigiosina
/
Ativação Linfocitária
/
Linfócitos T Citotóxicos
/
Imunossupressores
Limite:
Animals
Idioma:
En
Revista:
Transplantation
Ano de publicação:
1989
Tipo de documento:
Article
País de afiliação:
Japão
País de publicação:
Estados Unidos