ARLTS1, potential candidate gene in familial aggregation of hematological malignancies.
Bull Cancer
; 104(2): 123-127, 2017 Feb.
Article
em En
| MEDLINE
| ID: mdl-27866680
ABSTRACT
INTRODUCTION:
Genetic predisposition to familial hematological malignancies was previously described through several epidemiological analyses, but the genetic basis remains unclear. The tumor-suppressor ARLTS1 gene was previously described in sporadic hematological malignancies and familial cancer context.METHODS:
In this study, we sequence the ARLTS1 gene in 100 patients belonging to 88 independent Tunisian and French families.RESULTS:
After gene sequencing, we report 8 genetic variations, most of which were previously reported in several cancer forms. The most common variants were W149X and C148R and were previously associated to B-cell chronic lymphocytic leukemia and to high-risk of familial breast cancer.CONCLUSIONS:
These results emphasize the fact that ARLTS1 gene mutations can be considered as a potential predisposing factor in familial hematological malignancies and other several cancer forms.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Variação Genética
/
Genes Supressores de Tumor
/
Neoplasias Hematológicas
/
Predisposição Genética para Doença
/
Fatores de Ribosilação do ADP
Tipo de estudo:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Female
/
Humans
/
Male
País/Região como assunto:
Africa
/
Europa
Idioma:
En
Revista:
Bull Cancer
Ano de publicação:
2017
Tipo de documento:
Article