A Potential Biofilm Metabolite Signature for Caries Activity - A Pilot Clinical Study.
Metabolomics (Los Angel)
; 5(1)2015 Mar.
Article
em En
| MEDLINE
| ID: mdl-27885354
ABSTRACT
BACKGROUND:
This study's aim was to compare the dental biofilm metabolite-profile of caries-active (N=11) or caries-free (N=4) children by gas chromatography-mass spectrometry (GC/MS) analyses.METHODS:
Samples collected after overnight fasting, with or without a previous glucose rinse, were combined for each child based on the caries status of the site, re-suspended in ethanol and analyzed by GC/MS.RESULTS:
Biofilm from caries-active sites exhibited a different chromatographic profile compared to caries-free sites. Qualitative and quantitative analysis suggested a special cluster of branched alcohols and esters present at substantially higher intensity in biofilms of caries-active sites.CONCLUSIONS:
This pilot study indicates that there are metabolites present in the biofilm which have the potential to provide a characteristic metabolomics signature for caries activity.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Qualitative_research
Idioma:
En
Revista:
Metabolomics (Los Angel)
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Estados Unidos