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The pro-fibrotic role of dipeptidyl peptidase 4 in carbon tetrachloride-induced experimental liver injury.
Wang, Xin M; Holz, Lauren E; Chowdhury, Sumaiya; Cordoba, Shaun P; Evans, Kathryn A; Gall, Margaret G; Vieira de Ribeiro, Ana Júlia; Zheng, Yuan Zhou; Levy, Miriam T; Yu, Denise Mt; Yao, Tsun-Wen; Polak, Natasa; Jolly, Christopher J; Bertolino, Patrick; McCaughan, Geoffrey W; Gorrell, Mark D.
Afiliação
  • Wang XM; Centenary Institute and Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia.
  • Holz LE; A.W. Morrow Gastroenterology and Liver Centre, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia.
  • Chowdhury S; Centenary Institute and Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia.
  • Cordoba SP; Centenary Institute and Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia.
  • Evans KA; Centenary Institute and Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia.
  • Gall MG; Centenary Institute and Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia.
  • Vieira de Ribeiro AJ; Centenary Institute and Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia.
  • Zheng YZ; Centenary Institute and Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia.
  • Levy MT; Centenary Institute and Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia.
  • Yu DM; Centenary Institute and Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia.
  • Yao TW; A.W. Morrow Gastroenterology and Liver Centre, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia.
  • Polak N; Centenary Institute and Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia.
  • Jolly CJ; Centenary Institute and Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia.
  • Bertolino P; Centenary Institute and Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia.
  • McCaughan GW; Centenary Institute and Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia.
  • Gorrell MD; Centenary Institute and Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia.
Immunol Cell Biol ; 95(5): 443-453, 2017 05.
Article em En | MEDLINE | ID: mdl-27899813
ABSTRACT
Liver fibrosis is a progressive pathological process involving inflammation and extracellular matrix deposition. Dipeptidyl peptidase 4 (DPP4), also known as CD26, is a cell surface glycoprotein and serine protease. DPP4 binds to fibronectin, can inactivate specific chemokines, incretin hormone and neuropeptides, and influences cell adhesion and migration. Such properties suggest a pro-fibrotic role for this peptidase but this hypothesis needs in vivo examination. Experimental liver injury was induced with carbon tetrachloride (CCl4) in DPP4 gene knockout (gko) mice. DPP4 gko had less liver fibrosis and inflammation and fewer B cell clusters than wild type mice in the fibrosis model. DPP4 inhibitor-treated mice also developed less liver fibrosis. DNA microarray and PCR showed that many immunoglobulin (Ig) genes and some metabolism-associated transcripts were differentially expressed in the gko strain compared with wild type. CCl4-treated DPP4 gko livers had more IgM+ and IgG+ intrahepatic lymphocytes, and fewer CD4+, IgD+ and CD21+ intrahepatic lymphocytes. These data suggest that DPP4 is pro-fibrotic in CCl4-induced liver fibrosis and that the mechanisms of DPP4 pro-fibrotic action include energy metabolism, B cells, NK cells and CD4+ cells.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dipeptidil Peptidase 4 / Fígado / Cirrose Hepática Limite: Animals / Humans Idioma: En Revista: Immunol Cell Biol Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Austrália
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dipeptidil Peptidase 4 / Fígado / Cirrose Hepática Limite: Animals / Humans Idioma: En Revista: Immunol Cell Biol Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Austrália