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PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study.
Schmidt, Amand F; Swerdlow, Daniel I; Holmes, Michael V; Patel, Riyaz S; Fairhurst-Hunter, Zammy; Lyall, Donald M; Hartwig, Fernando Pires; Horta, Bernardo Lessa; Hyppönen, Elina; Power, Christine; Moldovan, Max; van Iperen, Erik; Hovingh, G Kees; Demuth, Ilja; Norman, Kristina; Steinhagen-Thiessen, Elisabeth; Demuth, Juri; Bertram, Lars; Liu, Tian; Coassin, Stefan; Willeit, Johann; Kiechl, Stefan; Willeit, Karin; Mason, Dan; Wright, John; Morris, Richard; Wanamethee, Goya; Whincup, Peter; Ben-Shlomo, Yoav; McLachlan, Stela; Price, Jackie F; Kivimaki, Mika; Welch, Catherine; Sanchez-Galvez, Adelaida; Marques-Vidal, Pedro; Nicolaides, Andrew; Panayiotou, Andrie G; Onland-Moret, N Charlotte; van der Schouw, Yvonne T; Matullo, Giuseppe; Fiorito, Giovanni; Guarrera, Simonetta; Sacerdote, Carlotta; Wareham, Nicholas J; Langenberg, Claudia; Scott, Robert; Luan, Jian'an; Bobak, Martin; Malyutina, Sofia; Pajak, Andrzej.
Afiliação
  • Schmidt AF; Institute of Cardiovascular Science, University College London, UK; Farr Institute of Health Informatics Research, UCL Institute of Health Informatics, University College London, UK. Electronic address: amand.schmidt@ucl.ac.uk.
  • Swerdlow DI; Institute of Cardiovascular Science, University College London, UK; Department of Medicine, Imperial College London, London, UK.
  • Holmes MV; Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK; Medical Research Council Population Health Research Unit at the University of Oxford, University of Oxford, Oxford, UK.
  • Patel RS; Institute of Cardiovascular Science, University College London, UK; Farr Institute of Health Informatics Research, UCL Institute of Health Informatics, University College London, UK; The Barts Heart Centre, St Bartholomew's Hospital, London, UK.
  • Fairhurst-Hunter Z; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
  • Lyall DM; Institute of Health & Wellbeing, University of Glasgow, Glasgow, UK.
  • Hartwig FP; Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil.
  • Horta BL; Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil.
  • Hyppönen E; Centre for Population Health Research, Sansom Institute for Health Research, University of South Australia, Adelaide, SA, Australia; Population, Policy and Practice, UCL Great Ormond Street Institute of Child Health, London, UK; South Australian Health and Medical Research Institute, Adelaide, SA, A
  • Power C; Population, Policy and Practice, UCL Great Ormond Street Institute of Child Health, London, UK.
  • Moldovan M; School of Health Sciences, University of South Australia, Adelaide, SA, Australia; South Australian Health and Medical Research Institute-EMBL Australia, Adelaide, SA, Australia.
  • van Iperen E; Durrer Center for Cardiovascular Research, Netherlands Heart Institute, Utrecht, Netherlands; Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center Amsterdam, Netherlands.
  • Hovingh GK; Department of Vascular Medicine, Academic Medical Center Amsterdam, Netherlands.
  • Demuth I; Charité Research Group on Geriatrics, Charité-Universitätsmedizin Berlin, Berlin, Germany; Institute of Medical and Human Genetics, Charité-Universitätsmedizin Berlin, Berlin, Germany.
  • Norman K; Charité Research Group on Geriatrics, Charité-Universitätsmedizin Berlin, Berlin, Germany.
  • Steinhagen-Thiessen E; Charité Research Group on Geriatrics, Charité-Universitätsmedizin Berlin, Berlin, Germany.
  • Demuth J; E.CA Economics GmbH, Berlin, Germany.
  • Bertram L; Neuroepidemiology and Ageing Research Unit, Imperial College London, London, UK; Lübeck Interdisciplinary Platform for Genome Analytics (LIGA), Institutes of Neurogenetics and Integrative and Experimental Genomics, University of Lübeck, Lübeck, Germany.
  • Liu T; Max Planck Institute for Human Development, Berlin, Germany; Max Planck Institute for Molecular Genetics, Berlin, Germany.
  • Coassin S; Division of Genetic Epidemiology Innsbruck, Department of Medical Genetics, Molecular and Clinical Pharmacology, Medical University of Innsbruck, Innsbruck, Austria.
  • Willeit J; Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
  • Kiechl S; Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
  • Willeit K; Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
  • Mason D; Bradford Institute for Health Research, Bradford Royal Infirmary, Bradford, UK.
  • Wright J; Bradford Institute for Health Research, Bradford Royal Infirmary, Bradford, UK.
  • Morris R; School of Social and Community Medicine, University of Bristol, Bristol, UK.
  • Wanamethee G; Department of Primary Care & Population Health, University College London, UK.
  • Whincup P; Population Health Research Institute, St George's, University of London, London, UK.
  • Ben-Shlomo Y; School of Social and Community Medicine, University of Bristol, Bristol, UK.
  • McLachlan S; Centre for Population Health Sciences, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
  • Price JF; Centre for Population Health Sciences, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
  • Kivimaki M; Department of Epidemiology and Public Health, UCL Institute of Epidemiology and Health Care, University College London, UK.
  • Welch C; Department of Epidemiology and Public Health, UCL Institute of Epidemiology and Health Care, University College London, UK.
  • Sanchez-Galvez A; Department of Epidemiology and Public Health, UCL Institute of Epidemiology and Health Care, University College London, UK.
  • Marques-Vidal P; Internal Medicine Unit, Department of Medicine, Lausanne University Hospital, Lausanne, Switzerland.
  • Nicolaides A; Department of Vascular Surgery, Imperial College London, London, UK; Department of Surgery, Nicosia Medical School, University of Nicosia, Nicosia, Cyprus.
  • Panayiotou AG; Cyprus International Institute for Environmental and Public Health, Cyprus University of Technology, Limassol, Cyprus.
  • Onland-Moret NC; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands.
  • van der Schouw YT; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands.
  • Matullo G; Human Genetics Foundation, HuGeF, Turin, Italy; Department of Medical Sciences, University of Turin, Turin, Italy.
  • Fiorito G; Human Genetics Foundation, HuGeF, Turin, Italy; Department of Medical Sciences, University of Turin, Turin, Italy.
  • Guarrera S; Human Genetics Foundation, HuGeF, Turin, Italy; Department of Medical Sciences, University of Turin, Turin, Italy.
  • Sacerdote C; Cancer Epidemiology Unit, San Giovanni Battista Hospital, Turin, Italy; Centre for Oncology Prevention, CPO Piemonte, Turin, Italy.
  • Wareham NJ; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, UK.
  • Langenberg C; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, UK.
  • Scott R; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, UK.
  • Luan J; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, UK.
  • Bobak M; Department of Epidemiology and Public Health, UCL Institute of Epidemiology and Health Care, University College London, UK.
  • Malyutina S; Novosibirsk State Medical University, Novosibirsk, Russia; Institute of Internal and Preventive Medicine, Siberian Branch of the Russian Academy of Medical Sciences, Novosibirsk, Russia.
  • Pajak A; Jagiellonian University Collegium Medicum, Krakow, Poland.
Lancet Diabetes Endocrinol ; 5(2): 97-105, 2017 02.
Article em En | MEDLINE | ID: mdl-27908689
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Variação Genética / Predisposição Genética para Doença / Diabetes Mellitus Tipo 2 / Análise da Randomização Mendeliana / Pró-Proteína Convertase 9 Tipo de estudo: Clinical_trials / Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Lancet Diabetes Endocrinol Ano de publicação: 2017 Tipo de documento: Article País de publicação: Reino Unido
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Variação Genética / Predisposição Genética para Doença / Diabetes Mellitus Tipo 2 / Análise da Randomização Mendeliana / Pró-Proteína Convertase 9 Tipo de estudo: Clinical_trials / Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Lancet Diabetes Endocrinol Ano de publicação: 2017 Tipo de documento: Article País de publicação: Reino Unido