Your browser doesn't support javascript.
loading
Cardiotoxic and Dyslipidemic Effects of Doxorubicin and Betulinic Acid Amide.
Klinnikova, M G; Lushnikova, E L; Koldysheva, E V; Tolstikova, T G; Sorokina, I V; Yuzhik, E I; Mzhelskaya, M M.
Afiliação
  • Klinnikova MG; Institute of Molecular Pathology and Pathomorphology; N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia. pathol@inbox.ru.
  • Lushnikova EL; Institute of Molecular Pathology and Pathomorphology; N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.
  • Koldysheva EV; Institute of Molecular Pathology and Pathomorphology; N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.
  • Tolstikova TG; Institute of Molecular Pathology and Pathomorphology; N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.
  • Sorokina IV; Institute of Molecular Pathology and Pathomorphology; N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.
  • Yuzhik EI; Institute of Molecular Pathology and Pathomorphology; N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.
  • Mzhelskaya MM; Institute of Molecular Pathology and Pathomorphology; N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.
Bull Exp Biol Med ; 162(2): 277-282, 2016 Dec.
Article em En | MEDLINE | ID: mdl-27913938
Changes in the blood lipid spectrum and structural reorganization of the rat myocardium in response to injection of a single sublethal dose of doxorubicin (7 mg/kg) alone and in combination with course administration of betulonic acid amide (100 mg/kg/day for 14 days) were studied. Betulinic acid amide in the specified dose exhibited less pronounced cardiotoxic (necrobiotic impairment of cardiomyocytes) and dyslipidemic (increase of cholesterol and triglyceride levels) effects in comparison with doxorubicin. Combined treatment with betulinic acid amide and doxorubicin led to more pronounced remodeling of the myocardium, which was shown by a significant increase of the connective tissue/cardiomyocyte volume ratio detected by day 14 of the experiment.
Assuntos
Palavras-chave
Buscar no Google
Adicionar na Minha BVS
Imprimir
XML
PubMed Links

Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Triterpenos / Doxorrubicina / Dislipidemias / Cardiotoxicidade / Antibióticos Antineoplásicos / Antineoplásicos Fitogênicos Tipo de estudo: Etiology_studies Limite: Animals Idioma: En Revista: Bull Exp Biol Med Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Federação Russa País de publicação: Estados Unidos
Buscar no Google
Adicionar na Minha BVS
Imprimir
XML
PubMed Links

Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Triterpenos / Doxorrubicina / Dislipidemias / Cardiotoxicidade / Antibióticos Antineoplásicos / Antineoplásicos Fitogênicos Tipo de estudo: Etiology_studies Limite: Animals Idioma: En Revista: Bull Exp Biol Med Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Federação Russa País de publicação: Estados Unidos