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Disease variants alter transcription factor levels and methylation of their binding sites.
Bonder, Marc Jan; Luijk, René; Zhernakova, Daria V; Moed, Matthijs; Deelen, Patrick; Vermaat, Martijn; van Iterson, Maarten; van Dijk, Freerk; van Galen, Michiel; Bot, Jan; Slieker, Roderick C; Jhamai, P Mila; Verbiest, Michael; Suchiman, H Eka D; Verkerk, Marijn; van der Breggen, Ruud; van Rooij, Jeroen; Lakenberg, Nico; Arindrarto, Wibowo; Kielbasa, Szymon M; Jonkers, Iris; van 't Hof, Peter; Nooren, Irene; Beekman, Marian; Deelen, Joris; van Heemst, Diana; Zhernakova, Alexandra; Tigchelaar, Ettje F; Swertz, Morris A; Hofman, Albert; Uitterlinden, André G; Pool, René; van Dongen, Jenny; Hottenga, Jouke J; Stehouwer, Coen D A; van der Kallen, Carla J H; Schalkwijk, Casper G; van den Berg, Leonard H; van Zwet, Erik W; Mei, Hailiang; Li, Yang; Lemire, Mathieu; Hudson, Thomas J; Slagboom, P Eline; Wijmenga, Cisca; Veldink, Jan H; van Greevenbroek, Marleen M J; van Duijn, Cornelia M; Boomsma, Dorret I; Isaacs, Aaron.
Afiliação
  • Bonder MJ; University of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, the Netherlands.
  • Luijk R; Molecular Epidemiology Section, Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, the Netherlands.
  • Zhernakova DV; University of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, the Netherlands.
  • Moed M; Molecular Epidemiology Section, Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, the Netherlands.
  • Deelen P; University of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, the Netherlands.
  • Vermaat M; University of Groningen, University Medical Center Groningen, Genomics Coordination Center, Groningen, the Netherlands.
  • van Iterson M; Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands.
  • van Dijk F; Molecular Epidemiology Section, Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, the Netherlands.
  • van Galen M; University of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, the Netherlands.
  • Bot J; University of Groningen, University Medical Center Groningen, Genomics Coordination Center, Groningen, the Netherlands.
  • Slieker RC; University of Groningen, University Medical Center Groningen, Genomics Coordination Center, Groningen, the Netherlands.
  • Jhamai PM; SURFsara, Amsterdam, the Netherlands.
  • Verbiest M; Molecular Epidemiology Section, Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, the Netherlands.
  • Suchiman HE; Department of Internal Medicine, ErasmusMC, Rotterdam, the Netherlands.
  • Verkerk M; University of Groningen, University Medical Center Groningen, Genomics Coordination Center, Groningen, the Netherlands.
  • van der Breggen R; Molecular Epidemiology Section, Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, the Netherlands.
  • van Rooij J; Department of Internal Medicine, ErasmusMC, Rotterdam, the Netherlands.
  • Lakenberg N; Molecular Epidemiology Section, Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, the Netherlands.
  • Arindrarto W; Department of Internal Medicine, ErasmusMC, Rotterdam, the Netherlands.
  • Kielbasa SM; Molecular Epidemiology Section, Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, the Netherlands.
  • Jonkers I; Medical Statistics Section, Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, the Netherlands.
  • van 't Hof P; Sequence Analysis Support Core, Leiden University Medical Center, Leiden, the Netherlands.
  • Nooren I; University of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, the Netherlands.
  • Beekman M; Sequence Analysis Support Core, Leiden University Medical Center, Leiden, the Netherlands.
  • Deelen J; SURFsara, Amsterdam, the Netherlands.
  • van Heemst D; Molecular Epidemiology Section, Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, the Netherlands.
  • Zhernakova A; Molecular Epidemiology Section, Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, the Netherlands.
  • Tigchelaar EF; Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands.
  • Swertz MA; University of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, the Netherlands.
  • Hofman A; University of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, the Netherlands.
  • Uitterlinden AG; University of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, the Netherlands.
  • Pool R; University of Groningen, University Medical Center Groningen, Genomics Coordination Center, Groningen, the Netherlands.
  • van Dongen J; Department of Epidemiology, ErasmusMC, Rotterdam, the Netherlands.
  • Hottenga JJ; Department of Internal Medicine, ErasmusMC, Rotterdam, the Netherlands.
  • Stehouwer CD; Department of Biological Psychology, Vrije Universiteit Amsterdam, Neuroscience Campus Amsterdam, Amsterdam, the Netherlands.
  • van der Kallen CJ; Department of Biological Psychology, Vrije Universiteit Amsterdam, Neuroscience Campus Amsterdam, Amsterdam, the Netherlands.
  • Schalkwijk CG; Department of Biological Psychology, Vrije Universiteit Amsterdam, Neuroscience Campus Amsterdam, Amsterdam, the Netherlands.
  • van den Berg LH; Department of Internal Medicine, Maastricht University Medical Center, Maastricht, the Netherlands.
  • van Zwet EW; School for Cardiovascular Diseases (CARIM), Maastricht University Medical Center, Maastricht, the Netherlands.
  • Mei H; Department of Internal Medicine, Maastricht University Medical Center, Maastricht, the Netherlands.
  • Li Y; School for Cardiovascular Diseases (CARIM), Maastricht University Medical Center, Maastricht, the Netherlands.
  • Lemire M; Department of Internal Medicine, Maastricht University Medical Center, Maastricht, the Netherlands.
  • Hudson TJ; School for Cardiovascular Diseases (CARIM), Maastricht University Medical Center, Maastricht, the Netherlands.
  • Slagboom PE; Medical Statistics Section, Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, the Netherlands.
  • Wijmenga C; Sequence Analysis Support Core, Leiden University Medical Center, Leiden, the Netherlands.
  • Veldink JH; University of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, the Netherlands.
  • van Greevenbroek MM; Ontario Institute for Cancer Research, Toronto, Ontario, Canada.
  • van Duijn CM; Ontario Institute for Cancer Research, Toronto, Ontario, Canada.
  • Boomsma DI; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.
  • Isaacs A; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
Nat Genet ; 49(1): 131-138, 2017 01.
Article em En | MEDLINE | ID: mdl-27918535
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fatores de Transcrição / Regulação da Expressão Gênica / Doença / Metilação de DNA / Polimorfismo de Nucleotídeo Único / Locos de Características Quantitativas Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Male / Middle aged Idioma: En Revista: Nat Genet Assunto da revista: GENETICA MEDICA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Holanda País de publicação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fatores de Transcrição / Regulação da Expressão Gênica / Doença / Metilação de DNA / Polimorfismo de Nucleotídeo Único / Locos de Características Quantitativas Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Male / Middle aged Idioma: En Revista: Nat Genet Assunto da revista: GENETICA MEDICA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Holanda País de publicação: Estados Unidos