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Constitutive activation of alternative nuclear factor kappa B pathway in canine diffuse large B-cell lymphoma contributes to tumor cell survival and is a target of new adjuvant therapies.
Seelig, Davis M; Ito, Daisuke; Forster, Colleen L; Yoon, Una A; Breen, Matthew; Burns, Linda J; Bachanova, Veronika; Lindblad-Toh, Kerstin; O'Brien, Timothy D; Schmechel, Stephen C; Rizzardi, Anthony E; Modiano, Jaime F; Linden, Michael A.
Afiliação
  • Seelig DM; a Department of Veterinary Clinical Sciences, College of Veterinary Medicine , University of Minnesota , St. Paul , MN , USA.
  • Ito D; b Masonic Cancer Center , University of Minnesota , Minneapolis , MN , USA.
  • Forster CL; a Department of Veterinary Clinical Sciences, College of Veterinary Medicine , University of Minnesota , St. Paul , MN , USA.
  • Yoon UA; b Masonic Cancer Center , University of Minnesota , Minneapolis , MN , USA.
  • Breen M; c The University of Minnesota Biological Materials Procurement Network (BioNet), University of Minnesota , Minneapolis , MN , USA.
  • Burns LJ; a Department of Veterinary Clinical Sciences, College of Veterinary Medicine , University of Minnesota , St. Paul , MN , USA.
  • Bachanova V; d Department of Molecular Biomedical Sciences, College of Veterinary Medicine , Center for Comparative Medicine and Translational Research, North Carolina State University , Raleigh , NC , USA.
  • Lindblad-Toh K; e Cancer Genetics Program , University of North Carolina Lineberger Comprehensive Cancer Center , Raleigh , NC , USA.
  • O'Brien TD; b Masonic Cancer Center , University of Minnesota , Minneapolis , MN , USA.
  • Schmechel SC; f Department of Medicine, Division of Hematology, Oncology, and Transplantation, School of Medicine , University of Minnesota , Minneapolis , MN , USA.
  • Rizzardi AE; b Masonic Cancer Center , University of Minnesota , Minneapolis , MN , USA.
  • Modiano JF; f Department of Medicine, Division of Hematology, Oncology, and Transplantation, School of Medicine , University of Minnesota , Minneapolis , MN , USA.
  • Linden MA; g Broad Institute of MIT and Harvard , Cambridge , MA , USA.
Leuk Lymphoma ; 58(7): 1702-1710, 2017 07.
Article em En | MEDLINE | ID: mdl-27931134
Activation of the classical nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB) pathway is a common molecular event observed in both human and canine diffuse large B-cell lymphoma (DLBCL). Although the oncogenic potential of the alternative NFκB pathway (ANFκBP) has also been recently identified in DLBCL, its precise role in tumor pathogenesis and potential as a treatment target is understudied. We hypothesized that up-regulation of the ANFκBP plays an important role in the proliferation and survival of canine DLBCL cells, and we demonstrate that the ANFκBP is constitutively active in primary canine DLBCL samples and a cell line (CLBL1). We further demonstrate that a small interfering RNA inhibits the activation of the NFκB pathway and induces apoptosis in canine DLBCL cells. In conclusion, the ANFκBP facilitates survival of canine DLBCL cells, and thus, dogs with spontaneous DLBCL can provide a useful large animal model to study therapies targeting the ANFκBP.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transdução de Sinais / NF-kappa B / Linfoma Difuso de Grandes Células B Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Leuk Lymphoma Assunto da revista: HEMATOLOGIA / NEOPLASIAS Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transdução de Sinais / NF-kappa B / Linfoma Difuso de Grandes Células B Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Leuk Lymphoma Assunto da revista: HEMATOLOGIA / NEOPLASIAS Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos