Fluoroquinolone consumption and -resistance trends in Mycobacterium tuberculosis and other respiratory pathogens: Ecological antibiotic pressure and consequences in Pakistan, 2009-2015.
Int J Mycobacteriol
; 5(4): 412-416, 2016 12.
Article
em En
| MEDLINE
| ID: mdl-27931682
ABSTRACT
OBJECTIVE/BACKGROUND:
Fluoroquinolones (FQs) are important anti-tuberculous drugs for the treatment of multidrug-resistant (MDR) tuberculosis. Resistance to FQs leads to fewer options for treatment of tuberculosis (TB), and infection with such strains may also require longer treatment duration. Trends of resistance in Mycobacterium tuberculosis (MTB) are indicators of MTB-resistance evolution. Drivers of such resistance need to be understood and studied to inform preventive strategies.METHODS:
Here, we present FQ-resistance rates and trends in Pakistan from 2010 to 2015 and compare rates with FQ-consumption data and rates in other community pathogens.RESULTS:
Our results reveal a recent decrease in FQ-resistance rates in MTB, but an increase in resistance for Haemophilus influenzae and Shigella spp. Correlation of FQ resistance with FQ consumption at the population level was weak for MTB, although strong associations were noted for H. influenzae and Shigella spp.CONCLUSION:
We discuss the possible reasons for the decrease in resistance rates in TB, putative drivers of resistance other than volume of FQ consumption, and the possible impact of the National Tuberculosis Programme and drug regulatory activities.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fluoroquinolonas
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Farmacorresistência Bacteriana
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Uso de Medicamentos
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Mycobacterium tuberculosis
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Antituberculosos
Limite:
Humans
País/Região como assunto:
Asia
Idioma:
En
Revista:
Int J Mycobacteriol
Ano de publicação:
2016
Tipo de documento:
Article
País de publicação:
IN
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INDIA
/
ÍNDIA