Dual activities of ritanserin and R59022 as DGK&#945; inhibitors and serotonin receptor antagonists.

Boroda, Salome; Niccum, Maria; Raje, Vidisha; Purow, Benjamin W; Harris, Thurl E

Dual activities of ritanserin and R59022 as DGKα inhibitors and serotonin receptor antagonists.

Boroda, Salome; Niccum, Maria; Raje, Vidisha; Purow, Benjamin W; Harris, Thurl E.

Afiliação

Boroda S; Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, VA 22903, USA.
Niccum M; Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, VA 22903, USA.
Raje V; Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, VA 22903, USA.
Purow BW; Department of Neurology, University of Virginia School of Medicine, Charlottesville, VA 22903, USA. Electronic address: bwp5g@virginia.edu.
Harris TE; Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, VA 22903, USA. Electronic address: teh3c@virginia.edu.

Biochem Pharmacol ; 123: 29-39, 2017 Jan 01.

Article em En | MEDLINE | ID: mdl-27974147

Assuntos

Diacilglicerol Quinase/antagonistas & inibidores; Inibidores Enzimáticos/farmacologia; Pirimidinonas/farmacologia; Ritanserina/farmacologia; Tiazóis/farmacologia; Trifosfato de Adenosina/metabolismo; Diacilglicerol Quinase/metabolismo; Eletroforese em Gel de Poliacrilamida; Células HEK293; Células HeLa; Humanos; Cinética

Palavras-chave

Diacylglycerol kinase (DGK); Diacylglycerol kinase inhibitor I (PubChem CID: 3012); Diacylglycerol kinase inhibitor II (PubChem CID: 657356); Ketanserin (PubChem CID: 3822).; Protein kinase C (PKC); R59022; Ritanserin; Ritanserin (PubChem CID: 5074); Serotonin receptor (5-HTR)

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirimidinonas / Tiazóis / Ritanserina / Diacilglicerol Quinase / Inibidores Enzimáticos Limite: Humans Idioma: En Revista: Biochem Pharmacol Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Reino Unido

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