A validated UPLC-MS/MS method for the analysis of linezolid and a novel oxazolidinone derivative (PH027) in plasma and its application to tissue distribution study in rabbits.

Hedaya, Mohsen A; Thomas, Vidhya; Abdel-Hamid, Mohamed E; Kehinde, Elijah O; Phillips, Oludotun A

Hedaya, Mohsen A; Thomas, Vidhya; Abdel-Hamid, Mohamed E; Kehinde, Elijah O; Phillips, Oludotun A.

Afiliação

Hedaya MA; Department of Pharmaceutics, Faculty of Pharmacy, Kuwait University, P.O. Box 24923, Safat 13110, Kuwait. Electronic address: mhedaya@hsc.edu.kw.
Thomas V; Department of Pharmaceutics, Faculty of Pharmacy, Kuwait University, P.O. Box 24923, Safat 13110, Kuwait. Electronic address: vidhya@HSC.EDU.KW.
Abdel-Hamid ME; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kuwait University, P.O. Box 24923, Safat 13110, Kuwait. Electronic address: abdel-hamid@HSC.EDU.KW.
Kehinde EO; Department of Surgery, Faculty of medicine, Kuwait University, P.O. Box 24923, Safat 13110, Kuwait. Electronic address: ekehinde@HSC.EDU.KW.
Phillips OA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kuwait University, P.O. Box 24923, Safat 13110, Kuwait. Electronic address: dphillips@HSC.EDU.KW.

J Chromatogr B Analyt Technol Biomed Life Sci ; 1040: 89-96, 2017 Jan 01.

Article em En | MEDLINE | ID: mdl-27978473

Assuntos

Antibacterianos/farmacocinética; Cromatografia Líquida de Alta Pressão/métodos; Linezolida/farmacocinética; Oxazolidinonas/farmacocinética; Espectrometria de Massas em Tandem/métodos; Triazóis/farmacocinética; Animais; Antibacterianos/sangue; Monitoramento de Medicamentos/métodos; Limite de Detecção; Linezolida/sangue; Oxazolidinonas/sangue; Coelhos; Distribuição Tecidual; Triazóis/sangue

Palavras-chave

Linezolid; Oxazolidinone antibacterial agents; Tissue analysis; Tissue distribution; UPLCMS/MS method validation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Triazóis / Cromatografia Líquida de Alta Pressão / Oxazolidinonas / Espectrometria de Massas em Tandem / Linezolida / Antibacterianos Limite: Animals Idioma: En Revista: J Chromatogr B Analyt Technol Biomed Life Sci Assunto da revista: ENGENHARIA BIOMEDICA Ano de publicação: 2017 Tipo de documento: Article País de publicação: Holanda

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