Rapid and strong de novo donor-specific antibody development in a lung transplant recipient: Short communication/case report.
Transpl Immunol
; 40: 17-21, 2017 02.
Article
em En
| MEDLINE
| ID: mdl-27979771
ABSTRACT
A 66-yo female patient (typed B*3901, 4402) underwent first left single lung transplant (typed B*8101, 1517) on 02/07/2016 with negative for DSA in current and historical samples. On 02/17/2016 strong de novo DSA (MFI=15,200, C1q+) to B81 were detected. The recipient has two children typed B*0702, 4402 B*2703, 3901, and had received multiple vaccinations. Twinrix, Zostavax and MMR vaccines contain viruses grown on live human lung fibroblasts (MRC-5, typed B*0702, 4402, and WI-38, typed B*0801, 5801). Each dose of vaccine used for injection is known to contain protein components of fibroblasts including HLA. Most likely rapid de novo DSA development is due to booster effect produced by five exposures to mismatched B locus alleles which share the following epitopes 70IAQ, 65QIA, 65QIA+76esn, 69aa+80n, and 163ew+73te. The later three consist of paired non-self and self eplets. Although likelihood of bystander effect produced by multiple vaccinations is low its impact cannot be ruled out.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Autoantígenos
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Vacinas
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Antígenos HLA-B
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Transplante de Pulmão
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Epitopos de Linfócito B
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Imunidade Humoral
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Imunidade Heteróloga
Limite:
Aged
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Female
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Humans
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Pregnancy
Idioma:
En
Revista:
Transpl Immunol
Assunto da revista:
ALERGIA E IMUNOLOGIA
/
TRANSPLANTE
Ano de publicação:
2017
Tipo de documento:
Article