Interaction of plant essential oil terpenoids with the southern cattle tick tyramine receptor: A potential biopesticide target.
Chem Biol Interact
; 263: 1-6, 2017 Feb 01.
Article
em En
| MEDLINE
| ID: mdl-27986436
ABSTRACT
An outbreak of the southern cattle tick, Rhipicephalus (Boophilus) microplus, (Canestrini), in the United States would have devastating consequences on the cattle industry. Tick populations have developed resistance to current acaricides, highlighting the need to identify new biochemical targets along with new chemistry. Furthermore, acaricide resistance could further hamper control of tick populations during an outbreak. Botanically-based compounds may provide a safe alternative for efficacious control of the southern cattle tick. We have developed a heterologous expression system that stably expresses the cattle tick's tyramine receptor with a G-protein chimera, producing a system that is amenable to high-throughput screening. Screening an in-house terpenoid library, at two screening concentrations (10 µM and 100 µM), has identified four terpenoids (piperonyl alcohol, 1,4-cineole, carvacrol and isoeugenol) that we believe are positive modulators of the southern cattle tick's tyramine receptor.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Terpenos
/
Carrapatos
/
Óleos Voláteis
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Receptores de Amina Biogênica
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Acaricidas
Limite:
Animals
Idioma:
En
Revista:
Chem Biol Interact
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Estados Unidos