Comment on "Structural basis of histone H3K27 trimethylation by an active polycomb repressive complex 2".
Science
; 354(6319): 1543, 2016 12 23.
Article
em En
| MEDLINE
| ID: mdl-28008037
Jiao and Liu (Research Articles, 16 October 2015, aac4383) reported the crystal structure of the protein complex polycomb repressive complex 2 from Chaetomium thermophilum This landmark structure has brought invaluable insights into the activation mechanism of this essential methyltransferase. However, the analysis of the x-ray data discussed below suggests that the description of oncogenic H3K27M peptide binding to the active site is incorrect.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Histonas
/
Complexo Repressor Polycomb 2
Idioma:
En
Revista:
Science
Ano de publicação:
2016
Tipo de documento:
Article
País de publicação:
Estados Unidos