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Comment on "Structural basis of histone H3K27 trimethylation by an active polycomb repressive complex 2".
Zhang, Ying; Justin, Neil; Wilson, Jon R; Gamblin, Steven J.
Afiliação
  • Zhang Y; Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK.
  • Justin N; Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK.
  • Wilson JR; Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK.
  • Gamblin SJ; Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK. steve.gamblin@crick.ac.uk.
Science ; 354(6319): 1543, 2016 12 23.
Article em En | MEDLINE | ID: mdl-28008037
Jiao and Liu (Research Articles, 16 October 2015, aac4383) reported the crystal structure of the protein complex polycomb repressive complex 2 from Chaetomium thermophilum This landmark structure has brought invaluable insights into the activation mechanism of this essential methyltransferase. However, the analysis of the x-ray data discussed below suggests that the description of oncogenic H3K27M peptide binding to the active site is incorrect.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Histonas / Complexo Repressor Polycomb 2 Idioma: En Revista: Science Ano de publicação: 2016 Tipo de documento: Article País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Histonas / Complexo Repressor Polycomb 2 Idioma: En Revista: Science Ano de publicação: 2016 Tipo de documento: Article País de publicação: Estados Unidos