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Atrial Natriuretic Peptide and Acute Changes in Central Blood Volume by Hyperthermia in Healthy Humans.
Vogelsang, Thomas Wiis; Marving, Jens; Crandall, Craig G; Wilson, Chad; Yoshiga, Chie C; Secher, Niels H; Hesse, Birger; Kjær, Andreas.
Afiliação
  • Vogelsang TW; Department of Clinical Physiology, Nuclear Medicine & PET, Rigshospitalet, Denmark ; Cluster for Molecular Imaging, University of Copenhagen, Denmark.
  • Marving J; Department of Clinical Physiology, Nuclear Medicine & PET, Rigshospitalet, Denmark.
  • Crandall CG; Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, Dallas, TX, USA ; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
  • Wilson C; Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, Dallas, TX, USA ; Department of Medicine, Pennsylvania State College of Medicine, Hershey, Pennsylvania, USA.
  • Yoshiga CC; Department of Anesthesia, Copenhagen Muscle Research Center, Rigshospitalet, University of Copenhagen, Denmark.
  • Secher NH; Department of Anesthesia, Copenhagen Muscle Research Center, Rigshospitalet, University of Copenhagen, Denmark.
  • Hesse B; Department of Clinical Physiology, Nuclear Medicine & PET, Rigshospitalet, Denmark.
  • Kjær A; Department of Clinical Physiology, Nuclear Medicine & PET, Rigshospitalet, Denmark ; Cluster for Molecular Imaging, University of Copenhagen, Denmark.
Open Neuroendocrinol J ; 5: 1-4, 2012.
Article em En | MEDLINE | ID: mdl-28018493
BACKGROUND: Hyperthermia induces vasodilatation that reduces central blood volume (CBV), central venous pressure (CVP) and mean arterial pressure (MAP). Inhibition of atrial natriuretic peptide (ANP) could be a relevant homeostatic defense mechanism during hyperthermia with a decrease in CBV. The present study evaluated how changes in plasma ANP reflect the changes in CBV during hyperthermia. METHODS: Ten healthy subjects provided with a water perfused body suit increased body core temperature 1 °C. In situ labeled autologous red blood cells were used to measure the CBV with a gamma camera. Regions of interest were traced manually on the images of the whole body blood pool scans. Two measures of CBV were used: Heart/whole body ratio and thorax/whole body ratio. CVP and MAP were recorded. Arterial (ANPart) and venous plasma ANP were determined by radioimmunoassay. RESULTS: The ratio thorax/whole body and heart/whole body decreased 7 % and 11 %, respectively (p<0.001). MAP and CVP decreased during hyperthermia by 6.8 and 5.0 mmHg, respectively (p<0.05; p<0.001). Changes in both thorax/whole body (R=0.80; p<0.01) and heart/whole body ratios (R=0.78; p<0.01) were correlated with changes in ANPart. However, there was no correlation between venous ANP and changes in CBV, nor between ANPart and MAP or CVP. CONCLUSION: Arterial but not venous plasma concentration of ANP, is correlated to changes in CBV, but not to pressures. We suggest that plasma ANPart may be used as a surrogate marker of acute CBV changes.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Open Neuroendocrinol J Ano de publicação: 2012 Tipo de documento: Article País de afiliação: Dinamarca País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Open Neuroendocrinol J Ano de publicação: 2012 Tipo de documento: Article País de afiliação: Dinamarca País de publicação: Estados Unidos