Concanavalin A reveals olfactory receptors which discriminate between alkane odorants on the basis of size.
Biochem J
; 262(2): 475-8, 1989 Sep 01.
Article
em En
| MEDLINE
| ID: mdl-2803264
ABSTRACT
For certain odorants, the amplitude of the rat electro-olfactogram is reduced if the olfactory epithelium is treated with the lectin concanavalin A. When normal and cycloalkanes of one to ten carbon atoms are used as odorants at equimolar concentration, the maximum reduction in amplitude is found to correlate with the size of the stimulus molecule. This observation is consistent with the notion that concanavalin A disables an olfactory receptor molecule which normally responds to the alkyl moiety of odorants in a particular size range. That moiety may thus represent a 'primary' quality-determining component in odour discrimination.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Células Receptoras Sensoriais
/
Mucosa Olfatória
/
Concanavalina A
/
Alcanos
/
Odorantes
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Biochem J
Ano de publicação:
1989
Tipo de documento:
Article
País de afiliação:
Reino Unido