Isolation and structure of ranamargarin, a new tachykinin from the skin of Chinese frog Rana margaratae.
Sci China B
; 32(5): 570-9, 1989 May.
Article
em En
| MEDLINE
| ID: mdl-2803524
ABSTRACT
A new tetradecapeptide, ranamargarin, has been isolated by Sep-Pak C18 and HPLC from methanol extracts of the skin of the Chinese frog Rana margaratae. The sequence of the peptide is Asp-Asp-Ala-Ser-Asp-Arg-Ala-Lys-Lys-Phe-Tyr-Gly-Leu-Met-NH2. This structure has been confirmed by synthesis. The peptide is the largest among the amphibian tachykinins and its N-terminal amino acids are quite different from those of the other tachykinins. The formation of the sulfoxide and peak-splitting of ranamargarin during purification procedures are briefly discussed.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pele
/
Taquicininas
Limite:
Animals
Idioma:
En
Revista:
Sci China B
Assunto da revista:
BIOLOGIA
/
CIENCIA
/
QUIMICA
Ano de publicação:
1989
Tipo de documento:
Article