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The effect of the top 20 Alzheimer disease risk genes on gray-matter density and FDG PET brain metabolism.
Stage, Eddie; Duran, Tugce; Risacher, Shannon L; Goukasian, Naira; Do, Triet M; West, John D; Wilhalme, Holly; Nho, Kwangsik; Phillips, Meredith; Elashoff, David; Saykin, Andrew J; Apostolova, Liana G.
Afiliação
  • Stage E; Department of Neurology, Indiana University School of Medicine, Indianapolis, IN, USA.
  • Duran T; Department of Neurology, Indiana University School of Medicine, Indianapolis, IN, USA.
  • Risacher SL; Department of Radiology and Imaging Sciences, Center for Neuroimaging, Indiana University School of Medicine, Indianapolis, IN, USA.
  • Goukasian N; Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
  • Do TM; Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
  • West JD; Department of Radiology and Imaging Sciences, Center for Neuroimaging, Indiana University School of Medicine, Indianapolis, IN, USA.
  • Wilhalme H; Department of Medicine Statistics Core, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
  • Nho K; Department of Radiology and Imaging Sciences, Center for Neuroimaging, Indiana University School of Medicine, Indianapolis, IN, USA.
  • Phillips M; Department of Neurology, Indiana University School of Medicine, Indianapolis, IN, USA.
  • Elashoff D; Department of Medicine Statistics Core, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
  • Saykin AJ; Department of Radiology and Imaging Sciences, Center for Neuroimaging, Indiana University School of Medicine, Indianapolis, IN, USA; Department of Medicine Statistics Core, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA; Indiana University Network Science Institute, Indianapolis, IN,
  • Apostolova LG; Department of Neurology, Indiana University School of Medicine, Indianapolis, IN, USA; Department of Radiology and Imaging Sciences, Center for Neuroimaging, Indiana University School of Medicine, Indianapolis, IN, USA; Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, C
Alzheimers Dement (Amst) ; 5: 53-66, 2016.
Article em En | MEDLINE | ID: mdl-28054028
ABSTRACT

INTRODUCTION:

We analyzed the effects of the top 20 Alzheimer disease (AD) risk genes on gray-matter density (GMD) and metabolism.

METHODS:

We ran stepwise linear regression analysis using posterior cingulate hypometabolism and medial temporal GMD as outcomes and all risk variants as predictors while controlling for age, gender, and APOE ε4 genotype. We explored the results in 3D using Statistical Parametric Mapping 8.

RESULTS:

Significant predictors of brain GMD were SLC24A4/RIN3 in the pooled and mild cognitive impairment (MCI); ZCWPW1 in the MCI; and ABCA7, EPHA1, and INPP5D in the AD groups. Significant predictors of hypometabolism were EPHA1 in the pooled, and SLC24A4/RIN3, NME8, and CD2AP in the normal control group.

DISCUSSION:

Multiple variants showed associations with GMD and brain metabolism. For most genes, the effects were limited to specific stages of the cognitive continuum, indicating that the genetic influences on brain metabolism and GMD in AD are complex and stage dependent.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Alzheimers Dement (Amst) Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Alzheimers Dement (Amst) Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Estados Unidos