XRCC1 Arg399Gln gene polymorphism and hepatocellular carcinoma risk in the Italian population.
Int J Biol Markers
; 32(2): e190-e194, 2017 May 04.
Article
em En
| MEDLINE
| ID: mdl-28058700
ABSTRACT
BACKGROUND:
The human X-ray repair cross-complementing protein 1 (XRCC1) gene encodes for one of the major repair factors involved in base excision repair (BER), which is reported to be associated with the risk of several cancers. A few studies have explored the association between risk of hepatocellular carcinoma (HCC) and single-nucleotide polymorphisms (SNPs) in different DNA repair genes, with contradictory results. The purpose of this study was to evaluate the association between XRCC1 Arg399Gln polymorphism and susceptibility to HCC.METHODS:
A total of 89 HCC patients and 99 randomly selected healthy controls were enrolled. Genotyping of XRCC1 rs25487 was performed by high-resolution melting analysis and Sanger sequencing.RESULTS:
On univariate analysis, a statistically significant association was found between risk of HCC and XRCC1 399Arg/Gln genotype (odd ratio [OR] = 1.88; 95% CI, 1.04-3.43), which was confirmed after adjusting by sex (OR = 1.94; 95% CI, 1.04-3.63). Although not significant, Kaplan-Meier analysis showed a decreased median survival in Arg/Gln genotype carriers in comparison with Arg/Arg carriers.CONCLUSIONS:
To our knowledge, this is the first study reporting an association between BER SNP and HCC risk in a population of central-southern Italy.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Carcinoma Hepatocelular
/
Predisposição Genética para Doença
/
Proteína 1 Complementadora Cruzada de Reparo de Raio-X
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Neoplasias Hepáticas
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Aged
/
Aged80
/
Female
/
Humans
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Male
/
Middle aged
País/Região como assunto:
Europa
Idioma:
En
Revista:
Int J Biol Markers
Assunto da revista:
BIOQUIMICA
/
NEOPLASIAS
Ano de publicação:
2017
Tipo de documento:
Article