The effect of glutamate on ghrelin release in mice.
Cell Biol Int
; 41(3): 320-327, 2017 Mar.
Article
em En
| MEDLINE
| ID: mdl-28067437
ABSTRACT
Ghrelin is abundantly produced in the stomach. Here, we found that glutamate decreased ghrelin expression and release in ghrelin-producing cells, and decreased levels of food intake and plasma acyl-ghrelin in mice. Treatment with siRNA of G protein-coupled receptor, family C, group 5, member B (GPRC5B) in ghrelin-producing cell lines completely blocked the effect of glutamate-induced ghrelin suppression. In addition, glutamate inhibited ghrelin release via the extracellular signal-regulated kinase (ERK) activity pathway, and stimulated CREB2 mRNA expression in ghrelin-producing cell lines. These results suggest that glutamate inhibits ghrelin release via ERK-CREB2 pathway. These results suggest that the GPRC5B-ERK-CREB2 pathway is involved in the inhibition of ghrelin expression and secretion in ghrelin cells.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ácido Glutâmico
/
Grelina
/
Mucosa Gástrica
Limite:
Animals
Idioma:
En
Revista:
Cell Biol Int
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Japão