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Discovery of Potent Cyclophilin Inhibitors Based on the Structural Simplification of Sanglifehrin A.
Steadman, Victoria A; Pettit, Simon B; Poullennec, Karine G; Lazarides, Linos; Keats, Andrew J; Dean, David K; Stanway, Steven J; Austin, Carol A; Sanvoisin, Jonathan A; Watt, Gregory M; Fliri, Hans G; Liclican, Albert C; Jin, Debi; Wong, Melanie H; Leavitt, Stephanie A; Lee, Yu-Jen; Tian, Yang; Frey, Christian R; Appleby, Todd C; Schmitz, Uli; Jansa, Petr; Mackman, Richard L; Schultz, Brian E.
Afiliação
  • Steadman VA; Selcia Ltd. , Fyfield Business & Research Park, Fyfield Road, Ongar, Essex CM5 0GS, United Kingdom.
  • Pettit SB; Selcia Ltd. , Fyfield Business & Research Park, Fyfield Road, Ongar, Essex CM5 0GS, United Kingdom.
  • Poullennec KG; Selcia Ltd. , Fyfield Business & Research Park, Fyfield Road, Ongar, Essex CM5 0GS, United Kingdom.
  • Lazarides L; Selcia Ltd. , Fyfield Business & Research Park, Fyfield Road, Ongar, Essex CM5 0GS, United Kingdom.
  • Keats AJ; Selcia Ltd. , Fyfield Business & Research Park, Fyfield Road, Ongar, Essex CM5 0GS, United Kingdom.
  • Dean DK; Selcia Ltd. , Fyfield Business & Research Park, Fyfield Road, Ongar, Essex CM5 0GS, United Kingdom.
  • Stanway SJ; Selcia Ltd. , Fyfield Business & Research Park, Fyfield Road, Ongar, Essex CM5 0GS, United Kingdom.
  • Austin CA; Selcia Ltd. , Fyfield Business & Research Park, Fyfield Road, Ongar, Essex CM5 0GS, United Kingdom.
  • Sanvoisin JA; Selcia Ltd. , Fyfield Business & Research Park, Fyfield Road, Ongar, Essex CM5 0GS, United Kingdom.
  • Watt GM; Selcia Ltd. , Fyfield Business & Research Park, Fyfield Road, Ongar, Essex CM5 0GS, United Kingdom.
  • Fliri HG; Cypralis Ltd. , Babraham Research Campus, Cambridge CB22 3AT, United Kingdom.
  • Liclican AC; Gilead Sciences , 333 Lakeside Drive, Foster City, California 94404, United States.
  • Jin D; Gilead Sciences , 333 Lakeside Drive, Foster City, California 94404, United States.
  • Wong MH; Gilead Sciences , 333 Lakeside Drive, Foster City, California 94404, United States.
  • Leavitt SA; Gilead Sciences , 333 Lakeside Drive, Foster City, California 94404, United States.
  • Lee YJ; Gilead Sciences , 333 Lakeside Drive, Foster City, California 94404, United States.
  • Tian Y; Gilead Sciences , 333 Lakeside Drive, Foster City, California 94404, United States.
  • Frey CR; Gilead Sciences , 333 Lakeside Drive, Foster City, California 94404, United States.
  • Appleby TC; Gilead Sciences , 333 Lakeside Drive, Foster City, California 94404, United States.
  • Schmitz U; Gilead Sciences , 333 Lakeside Drive, Foster City, California 94404, United States.
  • Jansa P; Gilead Sciences , 333 Lakeside Drive, Foster City, California 94404, United States.
  • Mackman RL; Gilead Sciences , 333 Lakeside Drive, Foster City, California 94404, United States.
  • Schultz BE; Gilead Sciences , 333 Lakeside Drive, Foster City, California 94404, United States.
J Med Chem ; 60(3): 1000-1017, 2017 02 09.
Article em En | MEDLINE | ID: mdl-28075591

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ciclofilinas Limite: Humans Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Reino Unido

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ciclofilinas Limite: Humans Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Reino Unido