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Polar aromatic periphery increases agonist potency of spirocyclic free fatty acid receptor (GPR40) agonists inspired by LY2881835.
Krasavin, Mikhail; Lukin, Alexey; Bagnyukova, Daria; Zhurilo, Nikolay; Golovanov, Aleksei; Zozulya, Sergey; Zahanich, Ihor; Moore, Daniel; Tikhonova, Irina G.
Afiliação
  • Krasavin M; Saint Petersburg State University, Saint Petersburg, 199034 Russian Federation. Electronic address: m.krasavin@spbu.ru.
  • Lukin A; Lomonosov Institute of Fine Chemical Technologies, Moscow Technological University, 86 Vernadskogo Prospekt, Moscow, 117571 Russian Federation.
  • Bagnyukova D; Lomonosov Institute of Fine Chemical Technologies, Moscow Technological University, 86 Vernadskogo Prospekt, Moscow, 117571 Russian Federation.
  • Zhurilo N; Lomonosov Institute of Fine Chemical Technologies, Moscow Technological University, 86 Vernadskogo Prospekt, Moscow, 117571 Russian Federation.
  • Golovanov A; Lomonosov Institute of Fine Chemical Technologies, Moscow Technological University, 86 Vernadskogo Prospekt, Moscow, 117571 Russian Federation.
  • Zozulya S; Enamine Ltd, 78 Chervonotkatska, Kyiv 02094, Ukraine; Taras Shevchenko National University, 62 Volodymyrska, Kyiv 01033, Ukraine.
  • Zahanich I; Enamine Ltd, 78 Chervonotkatska, Kyiv 02094, Ukraine.
  • Moore D; Molecular Therapeutics, School of Pharmacy, Medical Biology Centre, Queen's University Belfast, Belfast BT9 7BL, Northern Ireland, UK.
  • Tikhonova IG; Molecular Therapeutics, School of Pharmacy, Medical Biology Centre, Queen's University Belfast, Belfast BT9 7BL, Northern Ireland, UK.
Eur J Med Chem ; 127: 357-368, 2017 Feb 15.
Article em En | MEDLINE | ID: mdl-28076825
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piperidinas / Compostos de Espiro / Desenho de Fármacos / Receptores Acoplados a Proteínas G / Hipoglicemiantes Limite: Animals / Humans Idioma: En Revista: Eur J Med Chem Ano de publicação: 2017 Tipo de documento: Article País de publicação: França
Texto completo
Adicionar na Minha BVS
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XML
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Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piperidinas / Compostos de Espiro / Desenho de Fármacos / Receptores Acoplados a Proteínas G / Hipoglicemiantes Limite: Animals / Humans Idioma: En Revista: Eur J Med Chem Ano de publicação: 2017 Tipo de documento: Article País de publicação: França