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Structure-Based Design of Macrocyclic Factor XIa Inhibitors: Discovery of the Macrocyclic Amide Linker.
Corte, James R; Fang, Tianan; Osuna, Honey; Pinto, Donald J P; Rossi, Karen A; Myers, Joseph E; Sheriff, Steven; Lou, Zhen; Zheng, Joanna J; Harper, Timothy W; Bozarth, Jeffrey M; Wu, Yiming; Luettgen, Joseph M; Seiffert, Dietmar A; Decicco, Carl P; Wexler, Ruth R; Quan, Mimi L.
Afiliação
  • Corte JR; Research and Development, Bristol-Myers Squibb Company , P.O. Box 5400, Princeton, New Jersey 08543, United States.
  • Fang T; Research and Development, Bristol-Myers Squibb Company , P.O. Box 5400, Princeton, New Jersey 08543, United States.
  • Osuna H; Research and Development, Bristol-Myers Squibb Company , P.O. Box 5400, Princeton, New Jersey 08543, United States.
  • Pinto DJ; Research and Development, Bristol-Myers Squibb Company , P.O. Box 5400, Princeton, New Jersey 08543, United States.
  • Rossi KA; Research and Development, Bristol-Myers Squibb Company , P.O. Box 5400, Princeton, New Jersey 08543, United States.
  • Myers JE; Research and Development, Bristol-Myers Squibb Company , P.O. Box 5400, Princeton, New Jersey 08543, United States.
  • Sheriff S; Research and Development, Bristol-Myers Squibb Company , P.O. Box 5400, Princeton, New Jersey 08543, United States.
  • Lou Z; Research and Development, Bristol-Myers Squibb Company , P.O. Box 5400, Princeton, New Jersey 08543, United States.
  • Zheng JJ; Research and Development, Bristol-Myers Squibb Company , P.O. Box 5400, Princeton, New Jersey 08543, United States.
  • Harper TW; Research and Development, Bristol-Myers Squibb Company , P.O. Box 5400, Princeton, New Jersey 08543, United States.
  • Bozarth JM; Research and Development, Bristol-Myers Squibb Company , P.O. Box 5400, Princeton, New Jersey 08543, United States.
  • Wu Y; Research and Development, Bristol-Myers Squibb Company , P.O. Box 5400, Princeton, New Jersey 08543, United States.
  • Luettgen JM; Research and Development, Bristol-Myers Squibb Company , P.O. Box 5400, Princeton, New Jersey 08543, United States.
  • Seiffert DA; Research and Development, Bristol-Myers Squibb Company , P.O. Box 5400, Princeton, New Jersey 08543, United States.
  • Decicco CP; Research and Development, Bristol-Myers Squibb Company , P.O. Box 5400, Princeton, New Jersey 08543, United States.
  • Wexler RR; Research and Development, Bristol-Myers Squibb Company , P.O. Box 5400, Princeton, New Jersey 08543, United States.
  • Quan ML; Research and Development, Bristol-Myers Squibb Company , P.O. Box 5400, Princeton, New Jersey 08543, United States.
J Med Chem ; 60(3): 1060-1075, 2017 02 09.
Article em En | MEDLINE | ID: mdl-28085275
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fator XIa / Inibidores de Serina Proteinase / Compostos Macrocíclicos / Amidas Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fator XIa / Inibidores de Serina Proteinase / Compostos Macrocíclicos / Amidas Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos