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Multi-modal MRI investigation of volumetric and microstructural changes in the hippocampus and its subfields in mild cognitive impairment, Alzheimer's disease, and dementia with Lewy bodies.
Mak, Elijah; Gabel, Silvy; Su, Li; Williams, Guy B; Arnold, Robert; Passamonti, Luca; Vazquez Rodríguez, Patricia; Surendranathan, Ajenthan; Bevan-Jones, W Richard; Rowe, James B; O'Brien, John T.
Afiliação
  • Mak E; Department of Psychiatry,University of Cambridge,UK.
  • Gabel S; Department of Psychiatry,University of Cambridge,UK.
  • Su L; Department of Psychiatry,University of Cambridge,UK.
  • Williams GB; Wolfson Brain Imaging Centre,University of Cambridge,UK.
  • Arnold R; Department of Psychiatry,University of Cambridge,UK.
  • Passamonti L; Department of Clinical Neurosciences,University of Cambridge,Cambridge,UK.
  • Vazquez Rodríguez P; Department of Clinical Neurosciences,University of Cambridge,Cambridge,UK.
  • Surendranathan A; Department of Psychiatry,University of Cambridge,UK.
  • Bevan-Jones WR; Department of Psychiatry,University of Cambridge,UK.
  • Rowe JB; Department of Clinical Neurosciences,University of Cambridge,Cambridge,UK.
  • O'Brien JT; Department of Psychiatry,University of Cambridge,UK.
Int Psychogeriatr ; 29(4): 545-555, 2017 04.
Article em En | MEDLINE | ID: mdl-28088928
BACKGROUND: Volumetric atrophy and microstructural alterations in diffusion tensor imaging (DTI) measures of the hippocampus have been reported in people with Alzheimer's disease (AD) and mild cognitive impairment (MCI). However, no study to date has jointly investigated concomitant microstructural and volumetric changes of the hippocampus in dementia with Lewy bodies (DLB). METHODS: A total of 84 subjects (23 MCI, 17 DLB, 14 AD, and 30 healthy controls) were recruited for a multi-modal imaging (3T MRI and DTI) study that included neuropsychological evaluation. Freesurfer was used to segment the total hippocampus and delineate its subfields. The hippocampal segmentations were co-registered to the mean diffusivity (MD) and fractional anisotropy (FA) maps obtained from the DTI images. RESULTS: Both AD and MCI groups showed significantly smaller hippocampal volumes compared to DLB and controls, predominantly in the CA1 and subiculum subfields. Compared to controls, hippocampal MD was elevated in AD, but not in MCI. DLB was characterized by both volumetric and microstructural preservation of the hippocampus. In MCI, higher hippocampal MD was associated with greater atrophy of the hippocampus and CA1 region. Hippocampal volume was a stronger predictor of memory scores compared to MD within the MCI group. CONCLUSIONS: Through a multi-modal integration, we report novel evidence that the hippocampus in DLB is characterized by both macrostructural and microstructural preservation. Contrary to recent suggestions, our findings do not support the view that DTI measurements of the hippocampus are superior to volumetric changes in characterizing group differences, particularly between MCI and controls.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença por Corpos de Lewy / Doença de Alzheimer / Disfunção Cognitiva / Hipocampo Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Aged80 / Female / Humans / Male / Middle aged País/Região como assunto: Europa Idioma: En Revista: Int Psychogeriatr Assunto da revista: GERIATRIA / PSIQUIATRIA Ano de publicação: 2017 Tipo de documento: Article País de publicação: Reino Unido

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença por Corpos de Lewy / Doença de Alzheimer / Disfunção Cognitiva / Hipocampo Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Aged80 / Female / Humans / Male / Middle aged País/Região como assunto: Europa Idioma: En Revista: Int Psychogeriatr Assunto da revista: GERIATRIA / PSIQUIATRIA Ano de publicação: 2017 Tipo de documento: Article País de publicação: Reino Unido