Early-Life Social Isolation-Induced Depressive-Like Behavior in Rats Results in Microglial Activation and Neuronal Histone Methylation that Are Mitigated by Minocycline.

Wang, Hong-Tao; Huang, Fu-Lian; Hu, Zhao-Lan; Zhang, Wen-Juan; Qiao, Xiao-Qing; Huang, Yan-Qing; Dai, Ru-Ping; Li, Fang; Li, Chang-Qi

Wang, Hong-Tao; Huang, Fu-Lian; Hu, Zhao-Lan; Zhang, Wen-Juan; Qiao, Xiao-Qing; Huang, Yan-Qing; Dai, Ru-Ping; Li, Fang; Li, Chang-Qi.

Afiliação

Wang HT; Department of Anatomy and Neurobiology, School of Basic Medical Science, Central South University, Tongzipo Road 172, Changsha, Hunan, 410013, China.
Huang FL; Department of Anatomy and Neurobiology, School of Basic Medical Science, Central South University, Tongzipo Road 172, Changsha, Hunan, 410013, China.
Hu ZL; Department of Anatomy and Neurobiology, School of Basic Medical Science, Central South University, Tongzipo Road 172, Changsha, Hunan, 410013, China.
Zhang WJ; Department of Anatomy and Neurobiology, School of Basic Medical Science, Central South University, Tongzipo Road 172, Changsha, Hunan, 410013, China.
Qiao XQ; Department of Anatomy and Neurobiology, School of Basic Medical Science, Central South University, Tongzipo Road 172, Changsha, Hunan, 410013, China.
Huang YQ; Department of Anatomy and Neurobiology, School of Basic Medical Science, Central South University, Tongzipo Road 172, Changsha, Hunan, 410013, China.
Dai RP; Department of Anesthesia, the Second XiangYa Hospital, Central South University, Ren-Min Road 86, Changsha, Hunan, China.
Li F; Department of Anatomy and Neurobiology, School of Basic Medical Science, Central South University, Tongzipo Road 172, Changsha, Hunan, 410013, China. fangli@csu.edu.cn.
Li CQ; Department of Anatomy and Neurobiology, School of Basic Medical Science, Central South University, Tongzipo Road 172, Changsha, Hunan, 410013, China. changqili@csu.edu.cn.

Neurotox Res ; 31(4): 505-520, 2017 May.

Article em En | MEDLINE | ID: mdl-28092020

Assuntos

Depressão/metabolismo; Histonas/metabolismo; Microglia/metabolismo; Minociclina/farmacologia; Isolamento Social/psicologia; Animais; Proteínas de Ligação ao Cálcio/metabolismo; Citocinas/metabolismo; Modelos Animais de Doenças; Proteína 4 Homóloga a Disks-Large; Preferências Alimentares/efeitos dos fármacos; Hipocampo/metabolismo; Histona-Lisina N-Metiltransferase/metabolismo; Resposta de Imobilidade Tônica/efeitos dos fármacos; Interleucina-1beta/metabolismo; Peptídeos e Proteínas de Sinalização Intracelular/metabolismo; Masculino; Proteínas de Membrana/metabolismo; Metilação/efeitos dos fármacos; Proteínas dos Microfilamentos/metabolismo; Ratos; Receptores de AMPA/metabolismo; Receptores Imunológicos/metabolismo; Receptores de N-Metil-D-Aspartato/metabolismo

Palavras-chave

Depressive-like behavior; Early-life social isolation; H3K9me2; Microglia; Minocycline

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Isolamento Social / Histonas / Microglia / Depressão / Minociclina Tipo de estudo: Prognostic_studies / Risk_factors_studies Aspecto: Determinantes_sociais_saude Limite: Animals Idioma: En Revista: Neurotox Res Assunto da revista: NEUROLOGIA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: China País de publicação: Estados Unidos

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