SINE polymorphism reveals distinct strains of Entamoeba histolytica from North India.
Exp Parasitol
; 175: 28-35, 2017 Apr.
Article
em En
| MEDLINE
| ID: mdl-28131659
ABSTRACT
Entamoeba histolytica is an intestinal parasite causing significant morbidity and mortality in the developing world. More tools are needed to understand the epidemiology and molecular pathogenesis of amebiasis. Virulence pattern of E. histolytica could be linked with the genotype of a strain. Several loci showing insertion polymorphism of retrotransposable short interspersed nuclear elements EhSINE1 and EhSINE2 have been reported among laboratory strains of E. histolytica. The present study was undertaken to validate this observation in clinical isolates from north India. Our results indicate that the Indian samples show a different propensity of SINE retention or loss at two of the polymorphic loci compared with non-Indian samples. Statistical analysis of different loci revealed Locus 17 of EhSINE1as a potential geographical marker for distinguishing Indian isolates from non Indian isolates.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Polimorfismo Genético
/
DNA de Protozoário
/
Elementos Nucleotídeos Curtos e Dispersos
/
Entamoeba histolytica
/
Entamebíase
Limite:
Humans
País/Região como assunto:
Asia
Idioma:
En
Revista:
Exp Parasitol
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Índia