Click and Release: SO<sub>2</sub> Prodrugs with Tunable Release Rates.

Ji, Xingyue; El-Labbad, Eman M; Ji, Kaili; Lasheen, Deena S; Serya, Rabah A T; Abouzid, Khaled A; Wang, Binghe

Click and Release: SO₂ Prodrugs with Tunable Release Rates.

Ji, Xingyue; El-Labbad, Eman M; Ji, Kaili; Lasheen, Deena S; Serya, Rabah A T; Abouzid, Khaled A; Wang, Binghe.

Afiliação

Ji X; Department of Chemistry and Center for Diagnostics and Therapeutics, Georgia State University , Atlanta, Georgia 30303 United States.
El-Labbad EM; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ain Shams University , Abbassia, Cairo 11566, Egypt.
Ji K; Department of Chemistry and Center for Diagnostics and Therapeutics, Georgia State University , Atlanta, Georgia 30303 United States.
Lasheen DS; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ain Shams University , Abbassia, Cairo 11566, Egypt.
Serya RA; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ain Shams University , Abbassia, Cairo 11566, Egypt.
Abouzid KA; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ain Shams University , Abbassia, Cairo 11566, Egypt.
Wang B; Department of Chemistry and Center for Diagnostics and Therapeutics, Georgia State University , Atlanta, Georgia 30303 United States.

Org Lett ; 19(4): 818-821, 2017 02 17.

Article em En | MEDLINE | ID: mdl-28133965

ABSTRACT

ABSTRACT

Employing an intramolecular cycloaddition reaction, we have developed a series of SO2 prodrugs with tunable release rates with half-lives ranging from minutes to days.

Assuntos

Pró-Fármacos/química; Pró-Fármacos/metabolismo; Dióxido de Enxofre/química; Dióxido de Enxofre/metabolismo; Animais; Química Click; Reação de Cicloadição; Desenho de Fármacos; Liberação Controlada de Fármacos; Meia-Vida; Interações Hidrofóbicas e Hidrofílicas; Cinética; Camundongos; Estrutura Molecular; Células RAW 264.7; Relação Estrutura-Atividade

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dióxido de Enxofre / Pró-Fármacos Limite: Animals Idioma: En Revista: Org Lett Assunto da revista: BIOQUIMICA Ano de publicação: 2017 Tipo de documento: Article

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