Your browser doesn't support javascript.
loading
Implantable Tin Porphyrin-PEG Hydrogels with pH-Responsive Fluorescence.
Huang, Haoyuan; Chauhan, Saurabh; Geng, Jumin; Qin, Yiru; Watson, David F; Lovell, Jonathan F.
Afiliação
  • Huang H; Department of Biomedical Engineering and ‡Department of Chemistry, University at Buffalo, State University of New York , Buffalo, New York 14260, United States.
  • Chauhan S; Department of Biomedical Engineering and ‡Department of Chemistry, University at Buffalo, State University of New York , Buffalo, New York 14260, United States.
  • Geng J; Department of Biomedical Engineering and ‡Department of Chemistry, University at Buffalo, State University of New York , Buffalo, New York 14260, United States.
  • Qin Y; Department of Biomedical Engineering and ‡Department of Chemistry, University at Buffalo, State University of New York , Buffalo, New York 14260, United States.
  • Watson DF; Department of Biomedical Engineering and ‡Department of Chemistry, University at Buffalo, State University of New York , Buffalo, New York 14260, United States.
  • Lovell JF; Department of Biomedical Engineering and ‡Department of Chemistry, University at Buffalo, State University of New York , Buffalo, New York 14260, United States.
Biomacromolecules ; 18(2): 562-567, 2017 02 13.
Article em En | MEDLINE | ID: mdl-28146351
Tetracarboxy porphyrins can be polymerized with polyethylene glycol (PEG) diamines to generate hydrogels with intense, near-infrared, and transdermal fluorescence following subcutaneous implantation. Here, we show that the high density porphyrins of the preformed polymer can be chelated with tin via simple incubation. Tin porphyrin hydrogels exhibited increasing emission intensities, ratios, and lifetimes from pH 1 to 10. Tin porphyrin hydrogel emission was strongly reversible and pH responsiveness was observed in the physiological range between pH 6 and pH 8. pH-sensitive emission was detected via noninvasive transdermal fluorescence imaging in vivo following subcutaneous implantation in mice.
Assuntos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polietilenoglicóis / Polímeros / Porfirinas / Estanho / Hidrogéis / Fluorescência Limite: Animals Idioma: En Revista: Biomacromolecules Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polietilenoglicóis / Polímeros / Porfirinas / Estanho / Hidrogéis / Fluorescência Limite: Animals Idioma: En Revista: Biomacromolecules Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos