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Pharmacological inhibition of porcupine induces regression of experimental skin fibrosis by targeting Wnt signalling.
Chen, Chih-Wei; Beyer, Christian; Liu, Jun; Maier, Christiane; Li, Chun; Trinh-Minh, Thuong; Xu, Xiaohan; Cole, Stuart H; Hsieh, Mindy H; Ng, Nicholas; Althage, Alana; Meeusen, Shelly; Pan, Shifeng; Svensson, Eric C; Seidel, H Martin; Schett, Georg; Gergely, Peter; Harris, Jennifer L; Distler, Jörg H W.
Afiliação
  • Chen CW; Department of Medicine 3 for Rheumatology and Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany.
  • Beyer C; Department of Medicine 3 for Rheumatology and Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany.
  • Liu J; Genomics Institute of the Novartis Research Foundation, San Diego, California, USA.
  • Maier C; Department of Medicine 3 for Rheumatology and Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany.
  • Li C; Genomics Institute of the Novartis Research Foundation, San Diego, California, USA.
  • Trinh-Minh T; Department of Medicine 3 for Rheumatology and Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany.
  • Xu X; Department of Medicine 3 for Rheumatology and Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany.
  • Cole SH; Genomics Institute of the Novartis Research Foundation, San Diego, California, USA.
  • Hsieh MH; Genomics Institute of the Novartis Research Foundation, San Diego, California, USA.
  • Ng N; Genomics Institute of the Novartis Research Foundation, San Diego, California, USA.
  • Althage A; Genomics Institute of the Novartis Research Foundation, San Diego, California, USA.
  • Meeusen S; Genomics Institute of the Novartis Research Foundation, San Diego, California, USA.
  • Pan S; Genomics Institute of the Novartis Research Foundation, San Diego, California, USA.
  • Svensson EC; Translational Medicine Autoimmunity Novartis Institutes for Biomedical Research, Basel, Switzerland.
  • Seidel HM; Genomics Institute of the Novartis Research Foundation, San Diego, California, USA.
  • Schett G; Department of Medicine 3 for Rheumatology and Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany.
  • Gergely P; Translational Medicine Cardiovascular, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, USA.
  • Harris JL; Genomics Institute of the Novartis Research Foundation, San Diego, California, USA.
  • Distler JH; Department of Medicine 3 for Rheumatology and Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany.
Ann Rheum Dis ; 76(4): 773-778, 2017 04.
Article em En | MEDLINE | ID: mdl-28153829
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piperazinas / Esclerodermia Localizada / Escleroderma Sistêmico / Pele / Via de Sinalização Wnt / Aminopiridinas / Proteínas de Membrana Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Animals Idioma: En Revista: Ann Rheum Dis Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Alemanha País de publicação: Reino Unido
Texto completo
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piperazinas / Esclerodermia Localizada / Escleroderma Sistêmico / Pele / Via de Sinalização Wnt / Aminopiridinas / Proteínas de Membrana Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Animals Idioma: En Revista: Ann Rheum Dis Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Alemanha País de publicação: Reino Unido