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Analysis of efficacy obtained with a trivalent inactivated Haemophilus parasuis serovars 4, 5, and 12 vaccine and commercial vaccines against Glässer's disease in piglets.
Can J Vet Res ; 81(1): 22-27, 2017 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-28154458
ABSTRACT
The objective of this study was to assess the efficacy of a trivalent inactivated Haemophilus parasuis serovars 4, 5, and 12 vaccine with polymeric adjuvant gel (GEL) and commercial vaccines against Glässer's disease in piglets. Commercial vaccines containing inactivated H. parasuis serovars 4 and 5 (China), inactivated H. parasuis serovars 1 and 6 (Spain), and inactivated H. parasuis serovar 5 (USA) were also evaluated. Our results demonstrated that the trivalent inactivated H. parasuis serovars 4, 5, and 12 vaccine with GEL adjuvant can provide better protection against the 3 most common pathogenic serovars circulating in China than other commercial vaccines tested. Our findings also indicated that inactivated H. parasuis serovars 1 and 6 vaccine cross-protects piglets against H. parasuis serovars 4 and 5; inactivated H. parasuis serovar 5 vaccine cross-protects piglets against H. parasuis serovar 4 challenge; but none of the commercial vaccines tested in this study protected piglets against H. parasuis serovar 12. Our results provide a basis for further identification of common protective antigens that can induce cross-protection against heterogeneous serovars.
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Coleções: Bases de dados internacionais Base de dados: MEDLINE Assunto principal: Doenças dos Suínos / Vacinas Bacterianas / Haemophilus parasuis / Infecções por Haemophilus Limite: Animais Idioma: Inglês Revista: Can J Vet Res Assunto da revista: Medicina Veterinária Ano de publicação: 2017 Tipo de documento: Artigo