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Clear, Aqueous Topical Drop of Triamcinolone Acetonide.
Trinh, Hoang M; Cholkar, Kishore; Joseph, Mary; Yang, Xiaoyan; Mitra, Ashim K.
Afiliação
  • Trinh HM; Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, 5258 Health Science Building, 2464 Charlotte Street, Kansas City, Missouri, 64108-2718, USA.
  • Cholkar K; Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, 5258 Health Science Building, 2464 Charlotte Street, Kansas City, Missouri, 64108-2718, USA.
  • Joseph M; RiconPharma LLC, 100 Ford Road, Suite#9, Denville, New Jersey, 07834, USA.
  • Yang X; Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, 5258 Health Science Building, 2464 Charlotte Street, Kansas City, Missouri, 64108-2718, USA.
  • Mitra AK; Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, 5258 Health Science Building, 2464 Charlotte Street, Kansas City, Missouri, 64108-2718, USA.
AAPS PharmSciTech ; 18(7): 2466-2478, 2017 Oct.
Article em En | MEDLINE | ID: mdl-28185211
The objective of this study was to develop a clear aqueous mixed nanomicellar formulation (NMF) of triamcinolone acetonide (TA) with a combination of nonionic surfactant hydrogenated castor oil 60 (HCO-60) and octoxynol-40 (Oc-40). In order to delineate the effects of drug-polymer interactions on entrapment efficiency (EE), loading efficiency (LE), and critical micellar concentration (CMC), a design of experiment (DOE) was performed to optimize the formulation. In this study, full-factorial design has been used with HCO-60 and OC-40 as independent variables. All formulations were prepared following solvent evaporation and film rehydration method, characterized with size, polydispersity, shape, morphology, EE, LE, and CMC. A specific blend of HCO-60 and Oc-40 at a particular wt% ratio (5:1.5) produced highest drug EE, LE, and smallest CMC (0.0216 wt%). Solubility of TA in NMF improved 20 times relative to normal aqueous solubility. Qualitative 1H NMR studies confirmed the absence of free drug in the outer aqueous NMF medium. Moreover, TA-loaded NMF appeared to be highly stable and well tolerated on human corneal epithelial cells (HCEC) and human retinal pigment epithelial cells (D407 cells). Overall, these studies suggest that TA in NMF is safe and suitable for human topical ocular drop application.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Triancinolona Acetonida Tipo de estudo: Qualitative_research Limite: Animals / Humans Idioma: En Revista: AAPS PharmSciTech Assunto da revista: FARMACOLOGIA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Triancinolona Acetonida Tipo de estudo: Qualitative_research Limite: Animals / Humans Idioma: En Revista: AAPS PharmSciTech Assunto da revista: FARMACOLOGIA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos