Viral E6 is overexpressed via high viral load in invasive cervical cancer with episomal HPV16.

Hong, Die; Liu, Jia; Hu, Ying; Lu, Xiaonan; Li, Baohua; Li, Yang; Hu, Dongxiao; Lu, Weiguo; Xie, Xing; Cheng, Xiaodong

Hong, Die; Liu, Jia; Hu, Ying; Lu, Xiaonan; Li, Baohua; Li, Yang; Hu, Dongxiao; Lu, Weiguo; Xie, Xing; Cheng, Xiaodong.

Afiliação

Hong D; Department of Gynecologic Oncology, Women's Hospital, School of Medicine, Women's Reproductive Health Laboratory of Zhejiang Province, Zhejiang University, Xueshi Rd 1#, Hangzhou, 310006, China.
Liu J; Department of Gynecologic Oncology, Women's Hospital, School of Medicine, Women's Reproductive Health Laboratory of Zhejiang Province, Zhejiang University, Xueshi Rd 1#, Hangzhou, 310006, China.
Hu Y; Department of Gynecologic Oncology, Women's Hospital, School of Medicine, Women's Reproductive Health Laboratory of Zhejiang Province, Zhejiang University, Xueshi Rd 1#, Hangzhou, 310006, China.
Lu X; Department of Gynecologic Oncology, Women's Hospital, School of Medicine, Women's Reproductive Health Laboratory of Zhejiang Province, Zhejiang University, Xueshi Rd 1#, Hangzhou, 310006, China.
Li B; Department of Gynecologic Oncology, Women's Hospital, School of Medicine, Women's Reproductive Health Laboratory of Zhejiang Province, Zhejiang University, Xueshi Rd 1#, Hangzhou, 310006, China.
Li Y; Department of Gynecologic Oncology, Women's Hospital, School of Medicine, Women's Reproductive Health Laboratory of Zhejiang Province, Zhejiang University, Xueshi Rd 1#, Hangzhou, 310006, China.
Hu D; Department of Gynecologic Oncology, Women's Hospital, School of Medicine, Women's Reproductive Health Laboratory of Zhejiang Province, Zhejiang University, Xueshi Rd 1#, Hangzhou, 310006, China.
Lu W; Department of Gynecologic Oncology, Women's Hospital, School of Medicine, Women's Reproductive Health Laboratory of Zhejiang Province, Zhejiang University, Xueshi Rd 1#, Hangzhou, 310006, China.
Xie X; Department of Gynecologic Oncology, Women's Hospital, School of Medicine, Women's Reproductive Health Laboratory of Zhejiang Province, Zhejiang University, Xueshi Rd 1#, Hangzhou, 310006, China.
Cheng X; Department of Gynecologic Oncology, Women's Hospital, School of Medicine, Women's Reproductive Health Laboratory of Zhejiang Province, Zhejiang University, Xueshi Rd 1#, Hangzhou, 310006, China. chengxd@zju.edu.cn.

BMC Cancer ; 17(1): 136, 2017 02 15.

Article em En | MEDLINE | ID: mdl-28202002

Assuntos

Papillomavirus Humano 16/genética; Proteínas Oncogênicas Virais/genética; Infecções por Papillomavirus/genética; Plasmídeos/genética; Proteínas Repressoras/genética; Displasia do Colo do Útero/genética; Neoplasias do Colo do Útero/genética; Carga Viral/genética; Adulto; Idoso; Metilação de DNA; Feminino; Genoma Viral; Humanos; Pessoa de Meia-Idade; Invasividade Neoplásica; Infecções por Papillomavirus/patologia; Infecções por Papillomavirus/virologia; Reação em Cadeia da Polimerase; Neoplasias do Colo do Útero/patologia; Neoplasias do Colo do Útero/virologia; Integração Viral/genética; Adulto Jovem; Displasia do Colo do Útero/patologia; Displasia do Colo do Útero/virologia

Palavras-chave

Cervical cancer; Episome; HPV16; Integration; Oncogene expression; Viral load

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Plasmídeos / Proteínas Repressoras / Displasia do Colo do Útero / Neoplasias do Colo do Útero / Proteínas Oncogênicas Virais / Carga Viral / Infecções por Papillomavirus / Papillomavirus Humano 16 Limite: Adult / Aged / Female / Humans / Middle aged Idioma: En Revista: BMC Cancer Assunto da revista: NEOPLASIAS Ano de publicação: 2017 Tipo de documento: Article País de afiliação: China

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