Rationally Designed Peptide Probes for Extracellular Vesicles.
Adv Clin Chem
; 79: 25-41, 2017.
Article
em En
| MEDLINE
| ID: mdl-28212713
ABSTRACT
Extracellular vesicles (EVs) are submicroscopic lipid vesicles secreted from cells and play significant roles in cell-to-cell communication by transporting varieties of cell signaling molecules like proteins, DNA, mRNA, and microRNA. Recent studies showed that EVs are highly correlated with cancer progression and metastasis. However, there are some difficulties in probing each vesicle using popular analytical methods because of their small sizes and heterogeneous origins. These obstacles may be overcome by using a novel approach that senses highly curved membrane and negatively charged membrane lipids. In this chapter, we highlight the basic biological concepts of EVs, isolation, and quantification methods, and recent advent of peptide probes for EVs.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Peptídeos
/
Sondas Moleculares
Idioma:
En
Revista:
Adv Clin Chem
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Estados Unidos