Impact of acute fat mobilisation on the pharmacokinetics of the highly fat distributed compound TAK-357, investigated by physiologically based pharmacokinetic (PBPK) modeling and simulation.

Goto, Akihiko; Tagawa, Yoshihiko; Moriya, Yuu; Sato, Sho; Furukawa, Yoshiyuki; Wakabayashi, Takeshi; Tsukamoto, Tetsuya; DeJongh, Joost; van Steeg, Tamara J; Moriwaki, Toshiya; Asahi, Satoru

Goto, Akihiko; Tagawa, Yoshihiko; Moriya, Yuu; Sato, Sho; Furukawa, Yoshiyuki; Wakabayashi, Takeshi; Tsukamoto, Tetsuya; DeJongh, Joost; van Steeg, Tamara J; Moriwaki, Toshiya; Asahi, Satoru.

Afiliação

Goto A; Drug Metabolism and Pharmacokinetics Research Laboratories, Takeda Pharmaceutical Company Limited, Kanagawa, Japan.
Tagawa Y; Drug Metabolism and Pharmacokinetics Research Laboratories, Takeda Pharmaceutical Company Limited, Kanagawa, Japan.
Moriya Y; Drug Metabolism and Pharmacokinetics Research Laboratories, Takeda Pharmaceutical Company Limited, Kanagawa, Japan.
Sato S; Drug Metabolism and Pharmacokinetics Research Laboratories, Takeda Pharmaceutical Company Limited, Kanagawa, Japan.
Furukawa Y; Drug Safety Research Laboratories, Takeda Pharmaceutical Company Limited, Kanagawa, Japan.
Wakabayashi T; Central Nervous System Drug Discovery Unit, Takeda Pharmaceutical Company Limited, Kanagawa, Japan.
Tsukamoto T; Inflammation Drug Discovery Unit, Takeda Pharmaceutical Company Limited, Kanagawa, Japan.
DeJongh J; Leiden Advanced Pharmacokinetics & Pharmacodynamics (LAP&P) Consultants, Leiden, The Netherlands.
van Steeg TJ; Leiden Advanced Pharmacokinetics & Pharmacodynamics (LAP&P) Consultants, Leiden, The Netherlands.
Moriwaki T; Drug Metabolism and Pharmacokinetics Research Laboratories, Takeda Pharmaceutical Company Limited, Kanagawa, Japan.
Asahi S; Drug Metabolism and Pharmacokinetics Research Laboratories, Takeda Pharmaceutical Company Limited, Kanagawa, Japan.

Biopharm Drug Dispos ; 38(6): 373-380, 2017 Sep.

Article em En | MEDLINE | ID: mdl-28256717

Assuntos

Tecido Adiposo/metabolismo; Indenos/farmacocinética; Modelos Biológicos; Animais; Simulação por Computador; Cães; Indenos/sangue; Indenos/toxicidade; Masculino; Ratos Sprague-Dawley

Palavras-chave

PBPK; adipose tissue; body weight; fat mobilisation; lipophilic compound

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tecido Adiposo / Indenos / Modelos Biológicos Limite: Animals Idioma: En Revista: Biopharm Drug Dispos Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Japão País de publicação: Reino Unido

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