Relationship between antibody-dependent tumour cell lysis and primary granule exocytosis by human neutrophils.
Clin Exp Immunol
; 70(2): 479-83, 1987 Nov.
Article
em En
| MEDLINE
| ID: mdl-2827922
ABSTRACT
Neutrophil-mediated antibody-dependent cellular cytotoxicity (ADCC) against Raji target cells and neutrophil degranulation during the ADCC process were evaluated in the presence and in the absence of different agents able to interfere with the neutrophil release of granule components (anion channel blockers, colchicine, isoproterenol, dimethylxanthine, cAMP). When used at concentrations incapable of preventing the target cell recognition by neutrophils, the majority of these agents inhibited both the ADCC and the release of myeloperoxidase (MPO, primary granule marker) and lysozyme (LZM, primary and secondary granule marker). The inhibition of the ADCC correlated strictly with the inhibition of the MPO release. Thus, the results are consistent with the hypothesis that neutrophil primary granules play a major role in the cytolytic process.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Células Tumorais Cultivadas
/
Exocitose
/
Citotoxicidade Celular Dependente de Anticorpos
/
Neutrófilos
Limite:
Humans
Idioma:
En
Revista:
Clin Exp Immunol
Ano de publicação:
1987
Tipo de documento:
Article
País de afiliação:
Itália