Bone fracture in severe small-for-gestational-age, extremely low birth weight infants: A single-center analysis.
Early Hum Dev
; 106-107: 75-78, 2017.
Article
em En
| MEDLINE
| ID: mdl-28282531
ABSTRACT
INTRODUCTION:
Bone fracture is a complication of extremely low birth weight infants (ELBWIs). This study aimed to analyze risk factors for bone fracture in a population of severe small-for-gestational-age (SGA) ELBWIs.METHODS:
We retrospectively studied data from ELBWIs with a birth weight <1000g and <-2 standard deviations (SDs) born at the National Center for Child Health and Development, Japan, from 2013 to 2015. Infants were divided into fracture and control groups. Serum calcium (Ca) and phosphorus (P) levels, perinatal factors, and previously reported risk factors were analyzed.RESULTS:
Of 25 cases of severe SGA ELBWIs, 5 cases of bone fracture were identified. Gestational age was 27.7±2.2, 29.1±2.6weeks (mean difference [MD] -1.4, 95% confidence interval [CI] -4.0, -1.2, p=0.280), birth weight (BW) 448±105, 673±216g (MD -225, 95% CI -433, -17, p=0.036) and BW-SD -4.1±0.1, -3.4±0.8 (MD -0.8, 95% CI -1.5, -0.02, p=0.045) in the fracture and control groups, respectively. Minimums of serum Ca and P were 6.6±1.4, 8.1±0.8mg/dl (MD -1.5, 95% CI -2.5, -0.6), p=0.003) and 2.3±0.6, 3.5±1.1mg/dl (MD -1.2, 95% CI -2.2, -0.1, p=0.027) in the fracture and control groups, respectively.CONCLUSION:
Lower BW and BW-SD were possible risk factors for bone fracture. Hypocalcemia and hypophosphatemia may also contribute to the condition.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Hipofosfatemia
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Fraturas Ósseas
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Recém-Nascido de Peso Extremamente Baixo ao Nascer
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Hipocalcemia
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
Limite:
Child, preschool
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Female
/
Humans
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Infant
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Male
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Newborn
Idioma:
En
Revista:
Early Hum Dev
Ano de publicação:
2017
Tipo de documento:
Article