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Soybean polar lipids differently impact adipose tissue inflammation and the endotoxin transporters LBP and sCD14 in flaxseed vs. palm oil-rich diets.
Lecomte, Manon; Couëdelo, Leslie; Meugnier, Emmanuelle; Loizon, Emmanuelle; Plaisancié, Pascale; Durand, Annie; Géloën, Alain; Joffre, Florent; Vaysse, Carole; Michalski, Marie-Caroline; Laugerette, Fabienne.
Afiliação
  • Lecomte M; Univ-Lyon, CarMeN laboratory, INRA UMR1397, INSERM U1060, Université Claude Bernard Lyon 1, INSA-Lyon, IMBL, F-69621 Villeurbanne, France.
  • Couëdelo L; ITERG-ENMS, Université de Bordeaux, rue Léo Saignat, 33076 Bordeaux cedex, France.
  • Meugnier E; INRA UMR1397, CarMeN laboratory, Univ-Lyon, INSERM U1060, Université Claude Bernard Lyon 1, F-69921 Oullins, France.
  • Loizon E; INRA UMR1397, CarMeN laboratory, Univ-Lyon, INSERM U1060, Université Claude Bernard Lyon 1, F-69921 Oullins, France.
  • Plaisancié P; Univ-Lyon, CarMeN laboratory, INRA UMR1397, INSERM U1060, Université Claude Bernard Lyon 1, INSA-Lyon, IMBL, F-69621 Villeurbanne, France.
  • Durand A; Univ-Lyon, CarMeN laboratory, INRA UMR1397, INSERM U1060, Université Claude Bernard Lyon 1, INSA-Lyon, IMBL, F-69621 Villeurbanne, France.
  • Géloën A; Univ-Lyon, CarMeN laboratory, INRA UMR1397, INSERM U1060, Université Claude Bernard Lyon 1, INSA-Lyon, IMBL, F-69621 Villeurbanne, France.
  • Joffre F; ITERG-ENMS, Université de Bordeaux, rue Léo Saignat, 33076 Bordeaux cedex, France.
  • Vaysse C; ITERG-ENMS, Université de Bordeaux, rue Léo Saignat, 33076 Bordeaux cedex, France.
  • Michalski MC; Univ-Lyon, CarMeN laboratory, INRA UMR1397, INSERM U1060, Université Claude Bernard Lyon 1, INSA-Lyon, IMBL, F-69621 Villeurbanne, France.
  • Laugerette F; Univ-Lyon, CarMeN laboratory, INRA UMR1397, INSERM U1060, Université Claude Bernard Lyon 1, INSA-Lyon, IMBL, F-69621 Villeurbanne, France. Electronic address: fabienne.laugerette@univ-lyon1.fr.
J Nutr Biochem ; 43: 116-124, 2017 05.
Article em En | MEDLINE | ID: mdl-28284063
ABSTRACT
Obesity and type 2 diabetes are nutritional pathologies, characterized by a subclinical inflammatory state. Endotoxins are now well recognized as an important factor implicated in the onset and maintain of this inflammatory state during fat digestion in high-fat diet. As a preventive strategy, lipid formulation could be optimized to limit these phenomena, notably regarding fatty acid profile and PL emulsifier content. Little is known about soybean polar lipid (SPL) consumption associated to oils rich in saturated FA vs. anti-inflammatory omega-3 FA such as α-linolenic acid on inflammation and metabolic endotoxemia. We then investigated in mice the effect of different synthetic diets enriched with two different oils, palm oil or flaxseed oil and containing or devoid of SPL on adipose tissue inflammation and endotoxin receptors. In both groups containing SPL, adipose tissue (WAT) increased compared with groups devoid of SPL and an induction of MCP-1 and LBP was observed in WAT. However, only the high-fat diet in which flaxseed oil was associated with SPL resulted in both higher WAT inflammation and higher circulating sCD14 in plasma. In conclusion, we have demonstrated that LPS transporters LBP and sCD14 and adipose tissue inflammation can be modulated by SPL in high fat diets differing in oil composition. Notably high-flaxseed oil diet exerts a beneficial metabolic impact, however blunted by PL addition. Our study suggests that nutritional strategies can be envisaged by optimizing dietary lipid sources in manufactured products, including fats/oils and polar lipid emulsifiers, in order to limit the inflammatory impact of palatable foods.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Glycine max / Óleo de Semente do Linho / Proteínas de Fase Aguda / Glicoproteínas de Membrana / Paniculite / Proteínas de Transporte / Óleo de Palmeira Limite: Animals Idioma: En Revista: J Nutr Biochem Assunto da revista: BIOQUIMICA / CIENCIAS DA NUTRICAO Ano de publicação: 2017 Tipo de documento: Article País de afiliação: França

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Glycine max / Óleo de Semente do Linho / Proteínas de Fase Aguda / Glicoproteínas de Membrana / Paniculite / Proteínas de Transporte / Óleo de Palmeira Limite: Animals Idioma: En Revista: J Nutr Biochem Assunto da revista: BIOQUIMICA / CIENCIAS DA NUTRICAO Ano de publicação: 2017 Tipo de documento: Article País de afiliação: França