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Increased risk of stroke in patients with osteoarthritis: a population-based cohort study.
Hsu, P-S; Lin, H-H; Li, C-R; Chung, W-S.
Afiliação
  • Hsu PS; Department of Family Medicine, Taichung Hospital, Ministry of Health and Welfare, Taichung, Taiwan.
  • Lin HH; Department of Management Information Systems, Central Taiwan University of Science and Technology, Taichung, Taiwan.
  • Li CR; School of Nursing, Chung Shan Medical University, Taichung, Taiwan.
  • Chung WS; Department of Internal Medicine, Taichung Hospital, Ministry of Health and Welfare, Taichung, Taiwan; Department of Health Services Administration, China Medical University, Taichung, Taiwan; Department of Healthcare Administration, Central Taiwan University of Science and Technology, Taichung, Taiw
Osteoarthritis Cartilage ; 25(7): 1026-1031, 2017 07.
Article em En | MEDLINE | ID: mdl-28300652
OBJECTIVES: Osteoarthritis (OA) is related to carotid atherosclerosis. Few studies have investigated the incidence of cerebrovascular diseases in patients with OA. Therefore, we conducted a population-based cohort study to determine the incidence and risk of stroke in patients with OA. METHODS: We used data from Taiwan's Longitudinal Health Insurance Database 2000 (LHID2000) to investigate the incidence of stroke in 43,635 patients with OA newly diagnosed between 2002 and 2003. The non-osteoarthritis (non-OA) cohort comprised 43,635 people from the general population. The follow-up period was from the index date of OA to the date of censoring date or stroke diagnosis, or to the end of 2010. RESULTS: The overall incidence of stroke was 36% higher in the OA cohort than in the non-OA cohort, with an adjusted hazard ratio (aHR) of 1.10 (95% confidence interval [CI] = 1.06-1.14) after adjustment for covariates. Men, age, comorbidity, non-selective nonsteroidal anti-inflammatory drugs (NSAIDs), and Cox-2 selective NSAIDs are independent risk factors of stroke. The OA adults with mild to moderate OA (aHR = 1.97, 95% CI = 1.70-2.28 for young adults; aHR = 1.33, 95% CI = 1.25-1.42 for middle-aged adults; aHR = 1.16, 95% CI = 1.12-1.21 for older adults) and severe OA (aHR = 3.78, 95% CI = 2.50-5.70 for young adults; aHR = 1.34, 95% CI = 1.16-1.56 for middle-aged adults; and aHR = 1.01, 95% CI = 0.92-1.10 for older adults) exhibited increased risks of stroke compared with their counterparts without OA. CONCLUSION: OA may be associated with a slightly increased risk of stroke.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Osteoartrite / Acidente Vascular Cerebral Tipo de estudo: Etiology_studies / Observational_studies / Risk_factors_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País/Região como assunto: Asia Idioma: En Revista: Osteoarthritis Cartilage Assunto da revista: ORTOPEDIA / REUMATOLOGIA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Taiwan País de publicação: Reino Unido

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Osteoartrite / Acidente Vascular Cerebral Tipo de estudo: Etiology_studies / Observational_studies / Risk_factors_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País/Região como assunto: Asia Idioma: En Revista: Osteoarthritis Cartilage Assunto da revista: ORTOPEDIA / REUMATOLOGIA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Taiwan País de publicação: Reino Unido