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Five new koumine-type alkaloids from the roots of Gelsemium elegans.
Zhang, Wei; Zhang, Sheng-Yuan; Wang, Gui-Yang; Li, Ni-Ping; Chen, Min-Feng; Gu, Ji-Hong; Zhang, Dong-Mei; Wang, Lei; Ye, Wen-Cai.
Afiliação
  • Zhang W; Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, People's Republic of China; Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, People's Republic of China.
  • Zhang SY; Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, People's Republic of China; Medical College, Jiaying University, Meizhou 514031, People's Republic of China.
  • Wang GY; Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, People's Republic of China.
  • Li NP; Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, People's Republic of China.
  • Chen MF; Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, People's Republic of China.
  • Gu JH; Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, People's Republic of China.
  • Zhang DM; Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, People's Republic of China; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou 510632, People's Republic
  • Wang L; Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, People's Republic of China; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou 510632, People's Republic
  • Ye WC; Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, People's Republic of China; Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, People's Republic of China; Guangdong Province Key Laborato
Fitoterapia ; 118: 112-117, 2017 Apr.
Article em En | MEDLINE | ID: mdl-28300700
ABSTRACT
Five new koumine-type alkaloids (1-5) along with six known ones were isolated from the roots of Gelsemium elegans. Their structures with absolute configurations were elucidated on the basis of NMR spectroscopy and electronic circular dichroism spectral analyses. The inhibitory effects of compounds 1-11 on the viability of three tumor cell lines (A-649, HepG2, and HuH7) were evaluated by the MTT assay.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Alcaloides Indólicos / Gelsemium Limite: Humans Idioma: En Revista: Fitoterapia Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Alcaloides Indólicos / Gelsemium Limite: Humans Idioma: En Revista: Fitoterapia Ano de publicação: 2017 Tipo de documento: Article