Cell and region specificity of Aryl hydrocarbon Receptor (AhR) system in the testis and the epididymis.
Reprod Toxicol
; 69: 286-296, 2017 04.
Article
em En
| MEDLINE
| ID: mdl-28341572
ABSTRACT
Aryl hydrocarbon receptor (AhR) plays multiple important functions in adaptive responses. Exposure to AhR ligands may produce an altered metabolic activity controlled by the AhR pathways, and consequently affect drug/toxin responses, hormonal status and cellular homeostasis. This research revealed species-, cell- and region-specific pattern of the AhR system expression in the rat and human testis and epididymis, complementing the existing knowledge, especially within the epididymal segments. The study showed that AhR level in the rat and human epididymis is higher than in the testis. The downregulation of AhR expression after TCDD treatment was revealed in the spermatogenic cells at different stages and the epididymal epithelial cells, but not in the Sertoli and Leydig cells. Hence, this basic research provides information about the AhR function in the testis and epididymis, which may provide an insight into deleterious effects of drugs, hormones and environmental pollutants on male fertility.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Testículo
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Receptores de Hidrocarboneto Arílico
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Epididimo
Limite:
Aged
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Animals
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Reprod Toxicol
Assunto da revista:
EMBRIOLOGIA
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MEDICINA REPRODUTIVA
/
TOXICOLOGIA
Ano de publicação:
2017
Tipo de documento:
Article