Morphologic Change of Parvalbumin-positive Myelinated Axons in the Human Dental Pulp.
J Endod
; 43(6): 977-981, 2017 Jun.
Article
em En
| MEDLINE
| ID: mdl-28389070
ABSTRACT
INTRODUCTION:
Information on the nerve fibers innervating the dental pulp is crucial for understanding dental pain and hypersensitivity. This study investigated the morphologic differences of parvalbumin (PV)-positive (+) myelinated fibers in 3 different regions of the human dental pulp.METHODS:
Light and electron microscopic immunohistochemistry for parvalbumin, a marker for myelinated fibers, and quantitative analysis were performed in the apical root, core of coronal pulp, and peripheral pulp of human premolar teeth.RESULTS:
About 40% of the myelinated fibers in the apical root pulp became unmyelinated in the core of the coronal pulp, and virtually all the remaining fibers became unmyelinated at the peripheral pulp. The size of myelinated axons decreased from root to peripheral pulp. PV+ axons showed extensive axonal varicosities in the peripheral pulp.CONCLUSIONS:
These findings suggest that the myelinated fibers innervating the human dental pulp undergo extensive morphologic change in the extrapulpal region and in the coronal and peripheral pulp, and that PV-mediated regulation of calcium concentration and its downstream events may occur primarily in axonal varicosities in the peripheral pulp.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Parvalbuminas
/
Axônios
/
Polpa Dentária
/
Fibras Nervosas Mielinizadas
Limite:
Adolescent
/
Adult
/
Humans
Idioma:
En
Revista:
J Endod
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Coréia do Sul