FDG-PET in macrophage activation syndrome associated with systemic juvenile idiopathic arthritis.
Pediatr Int
; 59(4): 509-511, 2017 Apr.
Article
em En
| MEDLINE
| ID: mdl-28401744
ABSTRACT
We herein describe a case of systemic juvenile idiopathic arthritis (s-JIA)-associated macrophage activation syndrome (MAS) in which the 18F fluorodeoxyglucose positron emission tomography (18F FDG-PET) findings were characteristic. The pattern of greater 18F FDG accumulation into the spleen compared with the liver was more remarkable in this patient compared with s-JIA. This pattern, however, was also observed in cases of acute leukemia. In the present patient, serum interleukin (IL)-18 was extremely elevated (255 000 pg/mL), whereas in leukemia patients it is mildly elevated (360-1480 pg/mL). 18F FDG-PET might be a useful indicator of s-JIA and MAS in patients with fever of unknown origin. The pattern of 18F FDG accumulation, however, can also be observed in acute leukemia. The combination of 18F FDG-PET and serum IL-18 might be useful for the diagnosis of s-JIA and MAS.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Artrite Juvenil
/
Compostos Radiofarmacêuticos
/
Fluordesoxiglucose F18
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Tomografia por Emissão de Pósitrons
/
Síndrome de Ativação Macrofágica
Tipo de estudo:
Etiology_studies
/
Risk_factors_studies
Limite:
Child, preschool
/
Female
/
Humans
Idioma:
En
Revista:
Pediatr Int
Assunto da revista:
PEDIATRIA
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Japão