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Increased expression of deleted in malignant brain tumors (DMBT1) gene in precancerous gastric lesions: Findings from human and animal studies.
Garay, Jone; Piazuelo, M Blanca; Lopez-Carrillo, Lizbeth; Leal, Yelda A; Majumdar, Sumana; Li, Li; Cruz-Rodriguez, Nataly; Serrano-Gomez, Silvia J; Busso, Carlos S; Schneider, Barbara G; Delgado, Alberto G; Bravo, Luis E; Crist, Angela M; Meadows, Stryder M; Camargo, M Constanza; Wilson, Keith T; Correa, Pelayo; Zabaleta, Jovanny.
Afiliação
  • Garay J; Stanley S. Scott Cancer Center, LSUHSC, New Orleans, LA, USA.
  • Piazuelo MB; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Lopez-Carrillo L; Instituto Nacional de Salud Pública, Cuernavaca, Morelos, Mexico.
  • Leal YA; Unidad de Investigación Médica Yucatán de la Unidad Médica de Alta Especialidad (UMAE) del Instituto Mexicano del Seguro Social (IMSS), Yucatán, Mexico.
  • Majumdar S; Stanley S. Scott Cancer Center, LSUHSC, New Orleans, LA, USA.
  • Li L; Stanley S. Scott Cancer Center, LSUHSC, New Orleans, LA, USA.
  • Cruz-Rodriguez N; Stanley S. Scott Cancer Center, LSUHSC, New Orleans, LA, USA.
  • Serrano-Gomez SJ; Pontificia Universidad Javeriana, Bogotá, Colombia.
  • Busso CS; Grupo de Investigacion en Biología del Cáncer, Instituto Nacional de Cancerología, Bogotá, Colombia.
  • Schneider BG; Stanley S. Scott Cancer Center, LSUHSC, New Orleans, LA, USA.
  • Delgado AG; Pontificia Universidad Javeriana, Bogotá, Colombia.
  • Bravo LE; Grupo de Investigacion en Biología del Cáncer, Instituto Nacional de Cancerología, Bogotá, Colombia.
  • Crist AM; Department of Otorhinolaryngology, LSUHSC, New Orleans, LA, USA.
  • Meadows SM; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Camargo MC; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Wilson KT; Department of Pathology, Universidad del Valle, Cali, Colombia.
  • Correa P; Department of Cell and Molecular Biology Tulane University, New Orleans LA, USA.
  • Zabaleta J; Department of Cell and Molecular Biology Tulane University, New Orleans LA, USA.
Oncotarget ; 8(29): 47076-47089, 2017 Jul 18.
Article em En | MEDLINE | ID: mdl-28423364
Helicobacter pylori infection triggers a cascade of inflammatory stages that may lead to the appearance of non-atrophic gastritis, multifocal atrophic, intestinal metaplasia, dysplasia, and cancer. Deleted in malignant brain tumors 1 (DMBT1) belongs to the group of secreted scavenger receptor cysteine-rich proteins and is considered to be involved in host defense by binding to pathogens. Initial studies showed its deletion and loss of expression in a variety of tumors but the role of this gene in tumor development is not completely understood. Here, we examined the role of DMBT1 in gastric precancerous lesions in Caucasian, African American and Hispanic individuals as well as in the development of gastric pathology in a mouse model of H. pylori infection. We found that in 3 different populations, mucosal DMBT1 expression was significantly increased (2.5 fold) in individuals with dysplasia compared to multifocal atrophic gastritis without intestinal metaplasia; the increase was also observed in individuals with advanced gastritis and positive H. pylori infection. In our animal model, H. pylori infection of Dmbt1-/- mice resulted in significantly higher levels of gastritis, more extensive mucous metaplasia and reduced Il33 expression levels in the gastric mucosa compared to H. pylori-infected wild type mice. Our data in the animal model suggest that in response to H. pylori infection DMBT1 may mediate mucosal protection reducing the risk of developing gastric precancerous lesions. However, the increased expression in human gastric precancerous lesions points to a more complex role of DMBT1 in gastric carcinogenesis.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Lesões Pré-Cancerosas / Neoplasias Gástricas / Regulação Neoplásica da Expressão Gênica / Receptores de Superfície Celular Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Oncotarget Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Lesões Pré-Cancerosas / Neoplasias Gástricas / Regulação Neoplásica da Expressão Gênica / Receptores de Superfície Celular Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Oncotarget Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos