Regulation of mouse trophoblast giant cell nucleus development in hatched mouse blastocysts by cyclic cytidine 3',5'-monophosphate (cCMP).

ABSTRACT

The dibutyryl analog of cCMP enlarged the nuclei of trophoblast giant cells and promoted blastocyst development. The result suggests that cCMP has a trophic effect on embryonic development, specifically by altering the size of the trophoblast cell nucleus but does not enhance trophoblast cell proliferation processes.